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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 23 — Aug. 10, 2007
  • pp: 5991–6003

In vivo 783-channel diffuse reflectance imaging system and its application

Joon-Mo Yang, Yong-Hui Han, Gilwon Yoon, Byung Soo Ahn, Byung-Cheon Lee, and Kwang-Sup Soh  »View Author Affiliations


Applied Optics, Vol. 46, Issue 23, pp. 5991-6003 (2007)
http://dx.doi.org/10.1364/AO.46.005991


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Abstract

A fiber-based reflectance imaging system was constructed to produce in vivo absorption spectroscopic images of biological tissues with diffuse light in the cw domain. The principal part of this system is the 783-channel fiber probe, composed of 253 illumination fibers and 530 detection fibers distributed in a 20×20 mm square region. During illumination with the 253 illumination fibers, diffuse reflected lights are collected by the 530 detection fibers and recorded simultaneously as an image with an electron multiplying CCD camera for fast data acquisition. After signal acquisition, a diffuse reflectance image was reconstructed by applying the spectral normalization method we devised. To test the applicability of the spectral normalization, we conducted two phantom experiments with chicken breast tissue and white Delrin resin by using animal blood as an optical inhomogeneity. In the Delrin phantom experiment, we present images produced by two methods, spectral normalization and reference signal normalization, along with a comparison of the two. To show the feasibility of our system for biomedical applications, we took images of a human vein in vivo with the spectral normalization method.

© 2007 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(110.2350) Imaging systems : Fiber optics imaging
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Imaging Systems

History
Original Manuscript: July 3, 2006
Revised Manuscript: March 8, 2007
Manuscript Accepted: May 14, 2007
Published: August 9, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Joon-Mo Yang, Yong-Hui Han, Gilwon Yoon, Byung Soo Ahn, Byung-Cheon Lee, and Kwang-Sup Soh, "In vivo 783-channel diffuse reflectance imaging system and its application," Appl. Opt. 46, 5991-6003 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-23-5991

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