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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 24 — Aug. 20, 2007
  • pp: 6196–6209

Differential phase-contrast BioCD biosensor

Ming Zhao, Wonryeon Cho, Fred Regnier, and David Nolte  »View Author Affiliations


Applied Optics, Vol. 46, Issue 24, pp. 6196-6209 (2007)
http://dx.doi.org/10.1364/AO.46.006196


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Abstract

Common-path differential phase-contrast interferometry measures the spatial gradient of surface dipole density on a bio-optical compact disk (BioCD) and is sensitive to small changes in dipole density following molecular binding of target molecules out of solution. The recognition molecules are antibody IgG proteins that are deposited in periodic patterns on the BioCD using soft lithography or photolithography on the silanized silica surfaces of dielectric mirrors. Spatial carrier-wave sideband demodulation extracts the slowly varying protein envelope that modulates the protein carrier frequency. The experimental interferometric profilometry has surface height sensitivity down to 20 pm averaged over a lateral scale of 70 μm with a corresponding scaling mass sensitivity limit of 1.5 pg mm . Under the conditions of an IgG immunoassay with background changes caused during incubation, the scaling mass sensitivity is approximately 7 pg mm . A saturated reverse immunoassay performed with IgG at 100 ng ml showed false positive and false negative rates of 0.2%.

© 2007 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(260.3160) Physical optics : Interference

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 16, 2007
Manuscript Accepted: May 22, 2007
Published: August 20, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Ming Zhao, Wonryeon Cho, Fred Regnier, and David Nolte, "Differential phase-contrast BioCD biosensor," Appl. Opt. 46, 6196-6209 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-24-6196


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