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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 3 — Jan. 20, 2007
  • pp: 413–420

Laser–fiber system for ablation of intraocular tissue using the fourth harmonic of a pulsed Nd:YAG laser

Joseph Miller, Paula K. Yu, Stephen J. Cringle, and Dao-Yi Yu  »View Author Affiliations


Applied Optics, Vol. 46, Issue 3, pp. 413-420 (2007)
http://dx.doi.org/10.1364/AO.46.000413


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Abstract

Wereporton a method for delivering high fluence pulsed 266   nm laser radiation to the target tissue via an optical fiber. The fourth harmonic of a Nd:YAG laser was concentrated using a hollow glass taper and launched into an optical fiber. Fluences of up to 2 J / cm 2 were routinely output at the tapered optical fiber tip. The maximum fluence generated before failure of the optical fiber was between 3.5 and 8 J / cm 2 . Ablation of ocular tissue was demonstrated using fluences of 1.0 and 0.4 J / cm 2 . The delivery system has the potential for use in intraocular surgicalprocedures.

© 2007 Optical Society of America

OCIS Codes
(140.0140) Lasers and laser optics : Lasers and laser optics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1020) Medical optics and biotechnology : Ablation of tissue

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 8, 2006
Revised Manuscript: September 13, 2006
Manuscript Accepted: September 22, 2006
Published: January 4, 2007

Virtual Issues
Vol. 2, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Joseph Miller, Paula K. Yu, Stephen J. Cringle, and Dao-Yi Yu, "Laser-fiber system for ablation of intraocular tissue using the fourth harmonic of a pulsed Nd:YAG laser," Appl. Opt. 46, 413-420 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-3-413


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References

  1. M. H. Niemz, Laser-Tissue Interactions: Fundamentals and Applications (Markolf H. Niemz, 2002).
  2. R. W. Waynant, ed., Lasers in Medicine (CRC, 2002).
  3. A. Vogel and V. Venugopalan, "Mechanisms of pulsed laser ablation of biological tissues," Chem. Rev. 103, 577-644 (2003). [CrossRef] [PubMed]
  4. S. Borirakchanyavat, C. A. Puliafito, G. H. Kliman, T. I. Margolis, and E. L. Galler, "Holmium-YAG laser surgery on experimental vitreous membranes," Arch. Ophthalmol. 109, 1605-1609 (1991). [CrossRef] [PubMed]
  5. P. D. Brazitikos, D. J. D'Amico, M. T. Bernal, and A. W. Walsh, "Erbium:YAG laser surgery of the vitreous and retina," Ophthalmology 102, 278-290 (1995). [PubMed]
  6. S. M. Meyers, R. F. Bonner, M. M. Rodrigues, and E. J. Ballintine, "Phototransection of vitreal membranes with the carbon dioxide laser in rabbits," Ophthalmology 90, 563-568 (1983). [PubMed]
  7. D. Palanker, I. Hemo, I. Turovets, H. Zauberman, G. Fish, and A. Lewis, "Vitreoretinal ablation with the 193-nm excimer laser in fluid media," Invest. Ophthalmol. Visual Sci. 35, 3835-3840 (1994).
  8. I. Hemo, D. Palanker, I. Turovets, A. Lewis, and H. Zauberman, "Vitreoretinal surgery assisted by the 193-nm excimer laser," Invest. Ophthalmol. Visual Sci. 38, 1825-1829 (1997).
  9. G. Hillrichs, H. Dietz, M. Rutting, S. Schastak, P. Wiedemann, Y. Matsuura, M. Miyagi, and K. F. Klein, "Flexible beam guiding in a microsurgical UV laser scalpel," in Optical Fibers and Sensors for Medical Applications II, I. Gannot, ed., Proc. SPIE 4616, 199-206 (2002).
  10. M. Vogel and K. Lauritzen, "Selective excimer laser ablation of the trabecular meshwork. Clinical results," Ophthalmologe 94, 665-667 (1997). [CrossRef] [PubMed]
  11. F. G. Holz, A. Bindewald, F. Schutt, and H. Specht, "Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration," Biomed. Tech. 48, 82-85 (2003).
  12. E. H. Schallen, C. C. Awh, and E. Jr., de Juan, "Rate-dependent, nonlinear photoablation of ocular tissue at 308 nm," Lasers Surg. Med. 15, 99-106 (1994).
  13. M. J. Pellin, G. A. Williams, C. E. Young, D. M. Gruen, and M. A. Peters, "Endoexcimer laser intraocular ablative photodecomposition," Am. J. Ophthalmol. 99, 483-484 (1985). [PubMed]
  14. D. E. Williamson, "Cone channel condenser optics," J. Opt. Soc. Am. 42, 712-715 (1952). [CrossRef]
  15. D. G. Burkhard, G. L. Strobel, and D. L. Shealy, "Solar concentrating properties of truncated hexagonal, pyramidal and circular cones," Appl. Opt. 17, 2431-2449 (1978). [CrossRef] [PubMed]
  16. H. Schmidt-Kloiber and H. Schoeffmann, "Metallic hollow cones as light concentrators," Appl. Opt. 25, 252-257 (1986). [CrossRef] [PubMed]
  17. I. K. Ilev, R. W. Waynant, M. N. Ediger, and M. A. Bonaguidi, "Ultraviolet laser delivery using an uncoated hollow taper," IEEE J. Quantum Electron. 36, 944-948 (2000). [CrossRef]
  18. R. W. Waynant, I. K. Ilev, K. Mitra, I. Gannot, and R. J. Jennings, "Transmission characteristics of an all-optical-waveguide biomedical system for x-ray delivery," in Optical Fibers and Sensors for Medical Applications II, I. Gannot, ed., Proc. SPIE 4616, 121-128 (2002).
  19. I. K. Ilev and R. W. Waynant, "Uncoated hollow taper as a simple optical funnel for laser delivery," Rev. Sci. Instrum. 70, 3840-3843 (1999). [CrossRef]
  20. I. K. Ilev and R. W. Waynant, "Grazing-incidence-based hollow taper for infrared laser-to-fiber coupling," Appl. Phys. Lett. 74, 2921-2923 (1999). [CrossRef]
  21. A. Lewis, D. Palanker, I. Hemo, J. Pe'er, and H. Zauberman, "Microsurgery of the retina with a needle-guided 193-nm excimer laser," Invest. Ophthalmol. Visual Sci. 33, 2377-2381 (1992).
  22. P. K. Yu, J. Miller, S. J. Cringle, and D. Y. Yu, "Experimental retinal ablation using a fourth-harmonic 266 nm laser coupled with an optical fiber probe," Invest. Ophthalmol. Visual Sci. 47, 1587-1593 (2006). [CrossRef]
  23. D. Y. Yu, E. N. Su, S. J. Cringle, and P. K. Yu, "Isolated preparations of ocular vasculature and their applications in ophthalmic research," Prog. Retin. Eye Res. 22, 135-169 (2003). [CrossRef] [PubMed]
  24. G. E. Chamberlain, G. W. Day, D. L. Franzen, R. L. Gallawa, E. M. Kim, and M. Young, Optical Fiber Characterization. Attenuation, Frequency Domain Bandwidth, and Radiation Patterns, NBS-SP-637 [Natl. Bur. Stand. (U.S.), 1983].
  25. R. E. Setchell, "Optimized fiber delivery system for Q-switched Nd:YAG lasers," in Laser-Induced Damage in Optical Materials: 1996, H. E. Bennett, A. H. Guenther, M. R. Kozlowski, B. E. Newman, and M. J. Soileau, eds., Proc. SPIE 2966, 608-619 (1997). [CrossRef]
  26. N. Kuzuu, K. Yoshida, K. Ochi, Y. Tsuboi, T. Kamimura, H. Yoshida, and Y. Namba, "Laser-induced bulk damage of various types of silica glasses at 266 nm," Jpn. J. Appl. Phys. Part 1 43, 7174-7175 (2004). [CrossRef]
  27. D. P. Hand, J. D. Entwistle, R. R. Maier, A. Kuhn, C. A. Greated, and J. D. C. Jones, "Fibre optic beam delivery system for high peak power laser PIV illumination," Meas. Sci. Technol. 10, 239-245 (1999). [CrossRef]
  28. R. E. Setchell, "Laser injection optics for high-intensity transmission in multimode fibers," in Laser Beam Shaping, F. M. Dickey and S. C. Holswade, eds., Proc. SPIE 4095, 74-84 (2000). [CrossRef]

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