OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 33 — Nov. 20, 2007
  • pp: 8068–8073

Improving the sensitivity limit of surface plasmon resonance biosensors by detecting mixed interference signals

W. Yuan, H. P. Ho, Y. K. Suen, S. K. Kong, and Chinlon Lin  »View Author Affiliations


Applied Optics, Vol. 46, Issue 33, pp. 8068-8073 (2007)
http://dx.doi.org/10.1364/AO.46.008068


View Full Text Article

Enhanced HTML    Acrobat PDF (667 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We demonstrate that the sensitivity limit of intensity-based surface plasmon resonance (SPR) biosensors can be enhanced when we combine the effects of the phase and amplitude contributions instead of detecting the amplitude variation only. Experimental results indicate that an enhancement factor of as much as 20 times is achievable, yet with no compromise in measurement dynamic range. While existing SPR biosensor systems are predominantly based on the angular scheme, which relies on detecting intensity variations associated with amplitude changes only, the proposed scheme may serve as a direct system upgrade approach for these systems. The new measurement scheme may therefore lead to a strong impact in the design of SPR biosensors.

© 2007 Optical Society of America

OCIS Codes
(240.6680) Optics at surfaces : Surface plasmons
(240.6690) Optics at surfaces : Surface waves

ToC Category:
Remote Sensing and Sensors

History
Original Manuscript: July 5, 2007
Revised Manuscript: August 27, 2007
Manuscript Accepted: September 17, 2007
Published: November 19, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
W. Yuan, H. P. Ho, Y. K. Suen, S. K. Kong, and Chinlon Lin, "Improving the sensitivity limit of surface plasmon resonance biosensors by detecting mixed interference signals," Appl. Opt. 46, 8068-8073 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-33-8068

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited