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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 33 — Nov. 20, 2007
  • pp: 8080–8088

Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins

Bryan D. Dickerson, Brian L. Geist, William B. Spillman, Jr., and John L. Robertson  »View Author Affiliations


Applied Optics, Vol. 46, Issue 33, pp. 8080-8088 (2007)
http://dx.doi.org/10.1364/AO.46.008080


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Abstract

A cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, more accurate estimations of the concentrations of albumin, globulins, and hemoglobin in serum were obtained by fitting the near UV absorbance and photoluminescence spectra of diluted serum as a linear combination of component reference spectra. Tracking these serum proteins over the course of treatment helped to monitor patient immune response to carcinoma and therapy. For cancer screening, 70% of dogs with clinical presentation of cancer displayed suppressed serum hemoglobin levels (below 20 mg/dL) in combination with atypical serum protein compositions, that is, albumin levels outside of a safe range (from 4 to 8 g/dL) and globulin levels above or below a more normal range (from 1.7 to 3.7 g/dL). Of the dogs that met these criteria, only 20% were given a false positive label by this cancer screening test.

© 2007 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 22, 2007
Revised Manuscript: September 30, 2007
Manuscript Accepted: October 5, 2007
Published: November 19, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Bryan D. Dickerson, Brian L. Geist, William B. Spillman, Jr., and John L. Robertson, "Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins," Appl. Opt. 46, 8080-8088 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-33-8080

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