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Applied Optics

Applied Optics


  • Editor: James C. Wyant
  • Vol. 46, Iss. 34 — Dec. 1, 2007
  • pp: 8229–8236

Multispectral diffuse optical tomography with absorption and scattering spectral constraints

Changqing Li, Stephen R. Grobmyer, Lin Chen, Qizhi Zhang, Laurie L. Fajardo, and Huabei Jiang  »View Author Affiliations

Applied Optics, Vol. 46, Issue 34, pp. 8229-8236 (2007)

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We present a new method to simultaneously reconstruct the images of oxyhemoglobin, deoxyhemoglobin, and water concentrations, as well as the volume fraction images of the scattering particles using continuous wave multispectral diffuse optical tomography with the absorption and scattering spectral prior constraints. In this method, the nonlinear relationship between the reduced scattering coefficient and the volume fraction and the size of the particles is linearized, allowing direct reconstruction of the volume fraction of scattering particles in tissues. The method is validated by a series of numerical simulations, phantom experiments, and in vivo clinical experiments. The initial clinical results indicate that the volume fraction of scattering particles in a malignant tumor is higher than that in a benign tumor.

© 2007 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 8, 2007
Revised Manuscript: August 10, 2007
Manuscript Accepted: October 10, 2007
Published: November 26, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

Changqing Li, Stephen R. Grobmyer, Lin Chen, Qizhi Zhang, Laurie L. Fajardo, and Huabei Jiang, "Multispectral diffuse optical tomography with absorption and scattering spectral constraints," Appl. Opt. 46, 8229-8236 (2007)

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