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Applied Optics

Applied Optics


  • Editor: James C. Wyant
  • Vol. 46, Iss. 35 — Dec. 10, 2007
  • pp: 8506–8514

Fiber-based multispeckle detection for time-resolved diffusing-wave spectroscopy: characterization and application to blood flow detection in deep tissue

G. Dietsche, M. Ninck, C. Ortolf, J. Li, F. Jaillon, and T. Gisler  »View Author Affiliations

Applied Optics, Vol. 46, Issue 35, pp. 8506-8514 (2007)

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We present a technique for the measurement of temporal field autocorrelation functions of multiply scattered light with subsecond acquisition time. The setup is based on the parallel detection and autocorrelation of intensity fluctuations from statistically equivalent but independent speckles using a fiber bundle, an array of avalanche photodiodes, and a multichannel autocorrelator with variable integration times between 6.5 and 104 ms. Averaging the autocorrelation functions from the different speckles reduces the integration time in diffusing-wave spectroscopy experiments drastically, thus allowing us to resolve nonstationary scatterer dynamics with single-trial measurements. We present applications of the technique to the measurement of arterial and venous blood flow in deep tissue. We find strong deviations both of the shape and characteristic decay time of autocorrelation functions recorded at different phases of the pulsation cycle from time-averaged autocorrelation functions.

© 2007 Optical Society of America

OCIS Codes
(030.5260) Coherence and statistical optics : Photon counting
(030.6140) Coherence and statistical optics : Speckle
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Coherence and Statistical Optics

Original Manuscript: April 18, 2007
Revised Manuscript: August 30, 2007
Manuscript Accepted: October 11, 2007
Published: December 7, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics

G. Dietsche, M. Ninck, C. Ortolf, J. Li, F. Jaillon, and T. Gisler, "Fiber-based multispeckle detection for time-resolved diffusing-wave spectroscopy: characterization and application to blood flow detection in deep tissue," Appl. Opt. 46, 8506-8514 (2007)

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