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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 47, Iss. 12 — Apr. 20, 2008
  • pp: 2028–2034

Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy

Linda Persson, Märta Lewander, Mats Andersson, Katarina Svanberg, and Sune Svanberg  »View Author Affiliations


Applied Optics, Vol. 47, Issue 12, pp. 2028-2034 (2008)
http://dx.doi.org/10.1364/AO.47.002028


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Abstract

We report on a dual-diode laser spectroscopic system for simultaneous detection of two gases. The technique is demonstrated by performing gas measurements on absorbing samples such as an air distance, and on absorbing and scattering porous samples such as human tissue. In the latter it is possible to derive the concentration of one gas by normalizing to a second gas of known concentration. This is possible if the scattering and absorption of the bulk material is equal or similar for the two wavelengths used, resulting in a common effective pathlength. Two pigtailed diode lasers are operated in a wavelength modulation scheme to detect molecular oxygen 760 nm and water vapor 935 nm within the tissue optical window ( 600 nm to 1.3 μm ). Different modulation frequencies are used to distinguish between the two wavelengths. No crosstalk can be observed between the gas contents measured in the two gas channels. The system is made compact by using a computer board and performing software-based lock-in detection. The noise floor obtained corresponds to an absorption fraction of approximately 6 × 10 - 5 for both oxygen and water vapor, yielding a minimum detection limit of 2 mm for both gases in ambient air. The power of the technique is illustrated by the preliminary results of a clinical trial, nonintrusively investigating gas in human sinuses.

© 2008 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.7050) Medical optics and biotechnology : Turbid media
(300.1030) Spectroscopy : Absorption
(300.6260) Spectroscopy : Spectroscopy, diode lasers

ToC Category:
Spectroscopy

History
Original Manuscript: September 4, 2007
Revised Manuscript: February 8, 2008
Manuscript Accepted: February 28, 2008
Published: April 14, 2008

Virtual Issues
Vol. 3, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Linda Persson, Märta Lewander, Mats Andersson, Katarina Svanberg, and Sune Svanberg, "Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy," Appl. Opt. 47, 2028-2034 (2008)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-47-12-2028

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