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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 47, Iss. 3 — Jan. 20, 2008
  • pp: 365–371

Controlling the optical path length in turbid media using differential path-length spectroscopy: fiber diameter dependence

O. P. Kaspers, H. J. C. M. Sterenborg, and A. Amelink  »View Author Affiliations


Applied Optics, Vol. 47, Issue 3, pp. 365-371 (2008)
http://dx.doi.org/10.1364/AO.47.000365


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Abstract

We have characterized the path length for the differential path-length spectroscopy (DPS) fiber optic geometry for a wide range of optical properties and for fiber diameters ranging from 200   μm to 1000   μm . Phantom measurements show that the path length is nearly constant for scattering coefficients in the range 5 mm 1 < μ s < 50 mm 1 for all fiber diameters and that the path length is proportional to the fiber diameter. The path length decreases with increasing absorption for all fiber diameters, and this effect is more pronounced for larger fiber diameters. An empirical model is formulated that relates the DPS path length to total absorption for all fiber diameters simultaneously.

© 2008 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 2, 2007
Revised Manuscript: October 18, 2007
Manuscript Accepted: November 15, 2007
Published: January 15, 2008

Virtual Issues
Vol. 3, Iss. 2 Virtual Journal for Biomedical Optics

Citation
O. P. Kaspers, H. J. C. M. Sterenborg, and A. Amelink, "Controlling the optical path length in turbid media using differential path-length spectroscopy: fiber diameter dependence," Appl. Opt. 47, 365-371 (2008)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-47-3-365


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References

  1. J. R. Mourant, I. J. Bigio, D. A. Jack, T. M. Johnson, and H. D. Miller, "Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties," Appl. Opt. 36, 5655-5661 (1997). [CrossRef] [PubMed]
  2. A. Amelink and H. J. C. M. Sterenborg, "Measurement of the local optical properties of turbid media by differential path-length spectroscopy," Appl. Opt. 43, 3048-3054 (2004). [CrossRef] [PubMed]
  3. A. Amelink, O. P. Kaspers, H. J. C. M. Sterenborg, J. E. van der Wal, J. L. N. Roodenburg, and M. J. H. Witjes, "Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy," Oral Oncol. 44, 65-71 (2008). [CrossRef]
  4. C. S. Loh, A. J. MacRobert, J. Bedwell, J. Regula, N. Krasner, and S. G. Bown, "Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy," Br. J. Cancer 68, 41-51 (1993). [CrossRef] [PubMed]
  5. J. van den Boogert, R. van Hillegersberg, F. W. de Rooij, R. W. de Bruin, A. Edixhoven-Bosdijk, A. B. Houtsmuller, P. D. Siersema, J. H. Wilson, and H. W. Tilanus, "5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration," J. Photochem. Photobiol. B 44, 29-38 (1998). [CrossRef] [PubMed]
  6. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. C. Vangemert, "Optical properties of intralipid--a phantom medium for light-propagation studies," Lasers Surg. Med. 12, 510-519 (1992). [CrossRef] [PubMed]
  7. H. J. van Staveren, C. J. M. Moes, J. Vanmarle, S. A. Prahl, and M. J. C. Vangemert, "Light-scattering in Intralipid-10-percent in the wavelength range of 400-1100 nm," Appl. Opt. 30, 4507-4514 (1991). [CrossRef] [PubMed]
  8. R. M. P. Doornbos, R. Lang, M. C. Aalders, F. W. Cross, and H. J. C. M. Sterenborg, "The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy," Phys. Med. Biol. 44, 967-981 (1999). [CrossRef] [PubMed]
  9. A. J. Welch and M. J. C. van Gemert, eds., Optical-Thermal Response of Laser Irradiated Tissue (Plenum, 1995), pp. 280-300.
  10. N. Ghosh, S. K. Mohanty, S. K. Majumder, and P. K. Gupta, "Measurement of optical transport properties of normal and malignant human breast tissue," Appl. Opt. 40, 176-184 (2001). [CrossRef]
  11. J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner, and B. J. Tromberg, "Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject," Appl. Opt. 36, 10-20 (1997). [CrossRef] [PubMed]
  12. J. Qu, C. MacAulay, S. Lam, and B. Palcic, "Optical properties of normal and carcinomatous bronchial tissue," Appl. Opt. 33, 7397-7405 (1994). [CrossRef] [PubMed]
  13. J. R. Mourant, J. Boyer, A. H. Hielscher, and I. J. Bigio, "Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separation," Opt. Lett. 21, 546-548 (1996). [CrossRef] [PubMed]

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