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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 48, Iss. 10 — Apr. 1, 2009
  • pp: D26–D35

In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix

Judith R. Mourant, Tamara M. Powers, Thérese J. Bocklage, Heather M. Greene, Maxine H. Dorin, Alan G. Waxman, Meggan M. Zsemlye, and Harriet O. Smith  »View Author Affiliations


Applied Optics, Vol. 48, Issue 10, pp. D26-D35 (2009)
http://dx.doi.org/10.1364/AO.48.000D26


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Abstract

A noninvasive optical diagnostic system for detection of cancerous and precancerous lesions of the cervix was evaluated in vivo. The optical system included a fiber-optic probe designed to measure polarized and unpolarized light transport properties of a small volume of tissue. An algorithm for diagnosing tissue based on the optical measurements was developed that used four optical properties, three of which were related to light scattering properties and the fourth of which was related to hemoglobin concentration. A sensitivity of 77 % and specificities in the mid 60% range were obtained for separating high grade squamous intraepithelial lesions and cancer from other pathologies and normal tissue. The use of different cross-validation methods in algorithm development is analyzed, and the relative difficulties of diagnosing certain pathologies are assessed. Furthermore, the robustness of the optical system for use by different doctors and to changes in fiber-optic probe are also assessed, and potential improvements in the optical system are discussed.

© 2009 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(300.0300) Spectroscopy : Spectroscopy

History
Original Manuscript: June 30, 2008
Revised Manuscript: November 12, 2008
Manuscript Accepted: November 15, 2008
Published: January 7, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Judith R. Mourant, Tamara M. Powers, Thérese J. Bocklage, Heather M. Greene, Maxine H. Dorin, Alan G. Waxman, Meggan M. Zsemlye, and Harriet O. Smith, "In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix," Appl. Opt. 48, D26-D35 (2009)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-48-10-D26

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