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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 48, Iss. 10 — Apr. 1, 2009
  • pp: D36–D44

Extraction of near-axis scattered light for transillumination imaging

Kazuto Takagi, Yuji Kato, and Koichi Shimizu  »View Author Affiliations

Applied Optics, Vol. 48, Issue 10, pp. D36-D44 (2009)

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To suppress the scattering effect in transillumination imaging, a technique was developed to extract a near-axis scattered light (NASL) component from diffused light through a scattering medium. A diffuser is inserted between the light source and the incident surface of a scattering medium. We can extract the NASL component by subtracting the light intensity at the output surface with a diffuser from that without a diffuser. The principle to determine the subtraction weight was presented. In experiments using model phantoms of mammalian tissue, the proposed technique’s effectiveness was verified. The cross-section of the propagation area of scattered light was confined to an 8% area around the optical axis of the incident light beam. The usefulness of this technique was demonstrated by transillumination imag ing of the blood column through a diffuse medium.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.7050) Medical optics and biotechnology : Turbid media

Original Manuscript: July 17, 2008
Revised Manuscript: November 24, 2008
Manuscript Accepted: November 29, 2008
Published: January 9, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Kazuto Takagi, Yuji Kato, and Koichi Shimizu, "Extraction of near-axis scattered light for transillumination imaging," Appl. Opt. 48, D36-D44 (2009)

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  1. M. Kono, H. Ueki, and S. Umemura, “Near-infrared finger vein patterns for personal authentication,” Appl. Opt. 41, 7429-7434 (2002). [CrossRef] [PubMed]
  2. M. Kaneko, M. Hatakeyama, P. He, Y. Nakajima, H. Isoda, M. Takai, T. Okawada, M. Asumi, T. Kato, and S. Goto, “Construction of a laser transmission photo-scanner: pre-clinical investigation,” Radiat. Med. 7, 129-134 (1989). [PubMed]
  3. A. O. Wist, P. P. Fatouros, and S. L. Herr, “Increased spatial resolution in transillumination using collimated light,” IEEE Trans. Med. Imaging 12, 751-757 (1993). [CrossRef] [PubMed]
  4. J. C. Hebden, R. A. Kruger, and K. S. Wong, “Time resolved imaging through a highly scattering medium,” Appl. Opt. 30, 788-794 (1991). [CrossRef] [PubMed]
  5. J. C. Hebden, “Evaluating the spatial resolution performance of a time-resolved optical imaging system,” Med. Phys. 19, 1081-1087 (1992). [CrossRef] [PubMed]
  6. G. Mitic, J. Kolzer, J. Otto, E. Plies, G. Solkner, and W. Zinth, “Time-gated transillumination of biological and tissuelike phantoms,” Appl. Opt. 33, 6699-6710 (1994). [CrossRef] [PubMed]
  7. E. M. Sevick, J. R. Lakowicz, H. Szmacinski, K. Nowaczyk, and M. L. Johnson, “Frequency domain imaging of absorbers obscured by scattering,” J. Photochem. Photobiol. B 16, 169-185 (1992). [CrossRef] [PubMed]
  8. S. Charbonneau, L. B. Allard, J. F. Young, G. Dyck, and B. J. Kyle, “Two-dimensional time-resolved imaging with 100 ps resolution using a resistive anode photomultiplier tube,” Rev. Sci. Instrum. 63, 5315-5319 (1992). [CrossRef]
  9. R. Berg, O. Jarlman, and S. Svanberg, “Medical transillumination imaging using short-pulse diode lasers,” Appl. Opt. 32, 574-579 (1993). [CrossRef] [PubMed]
  10. D. A. Benaron, and D. K. Stevenson, “Optical time-of-flight and absorbance imaging of biologic media,” Science 259, 1463-1466 (1993). [CrossRef] [PubMed]
  11. L. Wang, P. P. Ho, G. Liu, G. Zhang, and R. R. Alfano, “Ballistic 2-D imaging through scattering walls using an ultrafast optical Kerr gate,” Science 253, 769-771 (1991). [CrossRef] [PubMed]
  12. K. M. Yoo, B. B. Das, and R. R. Alfano, “Imaging of a translucent object hidden in a highly scattering medium from the early portion of the diffuse component of a transmitted ultrafast laser pulse,” Opt. Lett. 17, 958-960 (1992). [CrossRef] [PubMed]
  13. L. Wang, P. P. Ho, and R. R. Alfano, “Time-resolved Fourier spectrum and imaging in highly scattering media,” Appl. Opt. 32, 5043-5048 (1993). [CrossRef] [PubMed]
  14. B. B. Das, K. M. Yoo, and R. R. Alfano, “Ultrafast time-gated imaging in thick tissue: a step toward optical mammography,” Opt. Lett. 18, 1092-1094 (1993). [CrossRef] [PubMed]
  15. Feng Liu, K. M. Yoo, and R. R. Alfano, “Transmitted photon intensity through biological tissue within various time windows,” Opt. Lett. 19, 740-742 (1994). [CrossRef] [PubMed]
  16. K. Shimizu and M. Kitama, “Fundamental study of near-axis scattered light and its application to optical computed tomography,” Opt. Rev. 7, 383-388 (2000). [CrossRef]
  17. K. Takagi, Y. Kato, M. Kitama, and K. Shimizu, “Application of time-resolved measurement technique to the detection of near-axis scattered light,” in Biomedical Topical Meetings, Technical Digest (Optical Society of America, 2000), paper TuF15-1.
  18. H. J. van Staveren, C. J. M. Moes, J. van Marle, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30, 4507-4514 (1991). [CrossRef] [PubMed]
  19. Valery Tuchin, Tissue Optics Light Scattering Methods and Instruments for Medical Diagnosis (SPIE, 2000).

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