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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 48, Iss. 24 — Aug. 20, 2009
  • pp: 4749–4755

Phase-contrast diffuse optical tomography for in vivo breast imaging: a two-step method

Ruixin Jiang, Xiaoping Liang, Qizhi Zhang, Stephen Grobmyer, Laurie L. Fajardo, and Huabei Jiang  »View Author Affiliations

Applied Optics, Vol. 48, Issue 24, pp. 4749-4755 (2009)

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We present a two-step reconstruction method that can qualitatively and quantitatively improve the reconstruction of tissue refractive index (RI) distribution by phase-contrast diffuse optical tomography (PCDOT). In this two-step method, we first recover the distribution of tissue absorption and scattering coefficients by conventional diffuse optical tomography to obtain the geometrical information of lesions, allowing the incorporation of geometrical information as a priori in the PCDOT reconstruction using a locally refined mesh. The method is validated by a series of phantom experiments and evaluated using in vivo data from 42 human subjects. The results demonstrate clear contrast of RI between the lesion and the surroundings, making the image interpretation straightforward. The sensitivity and specificity from these 42 cases are both 81% when RI is used as an imaging parameter for distinguishing between malignant and benign lesions.

© 2009 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3830) Medical optics and biotechnology : Mammography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 19, 2008
Revised Manuscript: July 4, 2009
Manuscript Accepted: July 30, 2009
Published: August 13, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Ruixin Jiang, Xiaoping Liang, Qizhi Zhang, Stephen Grobmyer, Laurie L. Fajardo, and Huabei Jiang, "Phase-contrast diffuse optical tomography for in vivo breast imaging: a two-step method," Appl. Opt. 48, 4749-4755 (2009)

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