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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 48, Iss. 33 — Nov. 20, 2009
  • pp: 6408–6416

Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies

Jiajia Ge, Sarah J. Erickson, and Anuradha Godavarty  »View Author Affiliations

Applied Optics, Vol. 48, Issue 33, pp. 6408-6416 (2009)

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Handheld-probe-based optical imagers are a popular approach toward breast imaging because of their potential portability and maximum patient comfort. A novel handheld-probe-based optical imager has been developed and its feasibility for three-dimensional fluorescence tomographic imaging demonstrated. Extensive tomography studies were performed on large slab phantoms ( 650 ml ) to assess the performance limits of the handheld imager. Experiments were performed by using different target volumes ( 0.1 0.45 cm 3 ), target depths ( 1 3 cm ), and fluorescence (Indocyanine Green) absorption contrast ratios in a nonfluorescing ( 1 0 ) and constant fluorescing backgrounds ( 1000 1 to 5 1 ). The estimated sensitivity and specificity of the handheld imager are 43% and 95%, respectively.

© 2009 Optical Society of America

OCIS Codes
(170.6960) Medical optics and biotechnology : Tomography
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 5, 2009
Revised Manuscript: October 21, 2009
Manuscript Accepted: October 23, 2009
Published: November 10, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Jiajia Ge, Sarah J. Erickson, and Anuradha Godavarty, "Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies," Appl. Opt. 48, 6408-6416 (2009)

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