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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 48, Iss. 34 — Dec. 1, 2009
  • pp: 6567–6574

Optimizing the spatial resolution of photonic crystal label-free imaging

Ian D. Block, Patrick C. Mathias, Sarah I. Jones, Lila O. Vodkin, and Brian T. Cunningham  »View Author Affiliations


Applied Optics, Vol. 48, Issue 34, pp. 6567-6574 (2009)
http://dx.doi.org/10.1364/AO.48.006567


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Abstract

A theory is derived to describe the relationship between photonic crystal (PC) label-free imaging resolution and PC resonance spectral linewidth and location. PCs are fabricated and patterned with a res olution standard photomask in order to verify this relationship experimentally. Two distinct linear resolutions of < 1 μm and 3.5 μm are demonstrated in orthogonal directions on a single device, where the former is limited by the imaging system optics and the latter is constrained by finite resonant mode propagation. In order to illustrate the utility of improved design control, the spectral response of a PC is optimized for label-free imaging of immobilized DNA capture spots on a microarray.

© 2009 Optical Society of America

OCIS Codes
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(050.5298) Diffraction and gratings : Photonic crystals

ToC Category:
Imaging Systems

History
Original Manuscript: June 19, 2009
Revised Manuscript: October 17, 2009
Manuscript Accepted: November 2, 2009
Published: November 20, 2009

Virtual Issues
Vol. 5, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Ian D. Block, Patrick C. Mathias, Sarah I. Jones, Lila O. Vodkin, and Brian T. Cunningham, "Optimizing the spatial resolution of photonic crystal label-free imaging," Appl. Opt. 48, 6567-6574 (2009)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-48-34-6567

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