OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 18 — Jun. 20, 2010
  • pp: 3538–3544

Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography

Peng Lee, Wanrong Gao, and Xianling Zhang  »View Author Affiliations


Applied Optics, Vol. 49, Issue 18, pp. 3538-3544 (2010)
http://dx.doi.org/10.1364/AO.49.003538


View Full Text Article

Enhanced HTML    Acrobat PDF (628 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Tissue optical properties can be determined with optical coherence tomography (OCT) by fitting a model to the OCT signal. Using calibrated samples in the fixed focus geometry, the validity of the single-scattering and multiple-scattering models for both highly scattering and weakly scattering media (scattering coefficients μ s ranging from 1.25 to 25.11 mm 1 ) has been investigated. The results show that, with a proper correction for the confocal properties of the sample arm, both models are appropriate to extract the scattering coefficients of weakly scattering media. For highly scattering media, the multiple scattering should be taken into account, and the multiple-scattering model can provide higher accuracy. Finally, the scattering properties of in vitro rat liver and in vivo human skin are determined. The results are useful for quantitatively characterizing tissue scattering in biomedical research and clinical diagnosis.

© 2010 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(290.5820) Scattering : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Imaging Systems

History
Original Manuscript: March 2, 2010
Revised Manuscript: May 20, 2010
Manuscript Accepted: May 28, 2010
Published: June 16, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Peng Lee, Wanrong Gao, and Xianling Zhang, "Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography," Appl. Opt. 49, 3538-3544 (2010)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-49-18-3538


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991). [CrossRef] [PubMed]
  2. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276, 2037–2039 (1997). [CrossRef] [PubMed]
  3. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12, 1429–1433 (2007). [CrossRef]
  4. D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photon. 1, 709–716 (2007). [CrossRef]
  5. E. M. Frohman, J. G. Fujimoto, T. C. Frohman, P. A. Calabresi, G. Cutter, and L. J. Balcer, “Optical coherence tomography: a window into the mechanisms of multiple sclerosis,” Nat. Clin. Pract. Neurol. 4, 664–675 (2008). [CrossRef] [PubMed]
  6. J. F. de Boer and T. E. Milner, “Review of polarization sensitive optical coherence tomography and Stokes vector determination,” J. Biomed. Opt. 7, 359–371 (2002). [CrossRef] [PubMed]
  7. J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9, 292–298(2004). [CrossRef] [PubMed]
  8. S. Sakai, M. Yamanari, A. Miyazawa, M. Matsumoto, N. Nakagawa, T. Sugawara, K. Kawabata, T. Yatagai, and Y. Yasuno, “In vivo three-dimensional birefringence analysis shows collagen differences between young and old photo-aged human skin,” J. Invest. Dermatol. 128, 1641–1647 (2008). [CrossRef] [PubMed]
  9. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, “Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity,” Opt. Lett. 25, 114–116 (2000). [CrossRef]
  10. Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, “Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography,” J. Biomed. Opt. 13, 064003 (2008). [CrossRef]
  11. Y. Wang, A. Lu, J. Gil-Flamer, O. Tan, J. A. Izatt, and D. Huang, “Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography,” Br. J. Ophthalmol. 93, 634–637 (2009). [CrossRef] [PubMed]
  12. J. M. Schmitt, S. H. Xiang, and K. M. Yung, “Differential absorption imaging with optical coherence tomography,” J. Opt. Soc. Am. A 15, 2288–2296 (1998). [CrossRef]
  13. C. Xu, J. Ye, D. L. Marks, and S. A. Boppart, “Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography,” Opt. Lett. 29, 1647–1649 (2004). [CrossRef] [PubMed]
  14. C. Xu, D. Marks, M. Do, and S. Boppart, “Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm,” Opt. Express 12, 4790–4803 (2004). [CrossRef] [PubMed]
  15. J. Schmitt, “OCT elastography: imaging microscopic deformation and strain of tissue,” Opt. Express 3, 199–211 (1998). [CrossRef] [PubMed]
  16. J. M. Schmitt, A. Knüttel, and R. F. Bonner, “Measurement of optical properties of biological tissues by low-coherence reflectometry,” Appl. Opt. 32, 6032–6042 (1993). [CrossRef] [PubMed]
  17. A. Knüttel and M. Boehlau-Godau, “Spatially confined and temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography,” J. Biomed. Opt. 5, 83–92 (2000). [CrossRef] [PubMed]
  18. D. Levitz, L. Thrane, M. Frosz, P. Andersen, C. Andersen, S. Andersson-Engels, J. Valanciunaite, J. Swartling, and P. Hansen, “Determination of optical scattering properties of highly-scattering media in optical coherence tomography images,” Opt. Express 12, 249–259 (2004). [CrossRef] [PubMed]
  19. F. J. van der Meer, D. J. Faber, D. M. Baraznji Sassoon, M. C. Aalders, G. Pasterkamp, and T. G. van Leeuwen, “Localized measurement of optical attenuation coefficients of atherosclerotic plaque constituents by quantitative optical coherence tomography,” IEEE Trans. Med. Imaging 24, 1369–1376(2005). [CrossRef] [PubMed]
  20. C. Xu, J. M. Schmitt, S. G. Carlier, and R. Virmani, “Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography,” J. Biomed. Opt. 13, 034003 (2008). [CrossRef] [PubMed]
  21. J. M. Schmitt and A. Knüttel, “Model of optical coherence tomography of heterogeneous tissue,” J. Opt. Soc. Am. A 14, 1231–1242 (1997). [CrossRef]
  22. L. Thrane, H. T. Yura, and P. E. Andersen, “Analysis of optical coherence tomography systems based on the extended Huygens–Fresnel principle,” J. Opt. Soc. Am. A 17, 484–490(2000). [CrossRef]
  23. D. Faber, F. van der Meer, M. Aalders, and T. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Opt. Express 12, 4353–4365 (2004). [CrossRef] [PubMed]
  24. H. J. van Staveren, C. J. M. Moes, J. van Marle, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400–1100nm,” Appl. Opt. 30, 4507–4514 (1991). [CrossRef] [PubMed]
  25. A. Giusto, R. Saija, M. A. Iatì, P. Denti, F. Borghese, and O. I. Sindoni, “Optical properties of high-density dispersions of particles: application to intralipid solutions,” Appl. Opt. 42, 4375–4380 (2003). [CrossRef] [PubMed]
  26. G. Zaccanti, S. Del Bianco, and F. Martelli, “Measurements of optical properties of high-density media,” Appl. Opt. 42, 4023–4030 (2003). [CrossRef] [PubMed]
  27. T. L. Troy and S. N. Thennadil, “Optical properties of human skin in the near infrared wavelength range of 1000 to 2200nm,” J. Biomed. Opt. 6, 167–176 (2001). [CrossRef] [PubMed]
  28. R. C. Weast, Handbook of Chemistry and Physics (CRC, 1978).
  29. S. Prahl, http://omlc.ogi.edu/calc/mie_calc.html.
  30. J. M. Schmitt, S. H. Xiang, and K. M. Yung, “Speckle in optical coherence tomography,” J. Biomed. Opt. 4, 95–105 (1999). [CrossRef]
  31. A. I. Kholodnykh, I. Y. Petrova, K. V. Larin, M. Motamedi, and R. O. Esenaliev, “Precision of measurement of tissue optical properties with optical coherence tomography,” Appl. Opt. 42, 3027–3037 (2003). [CrossRef] [PubMed]
  32. T. G. van Leeuwen, D. J. Faber, and M. C. Aalders, “Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron. 9, 227–233 (2003). [CrossRef]
  33. G. Vargas, E. K. Chan, J. K. Barton, H. G. Rylander, and A. J. Welch, “Use of an agent to reduce scattering in skin,” Lasers Surg. Med. 24, 133–141 (1999). [CrossRef] [PubMed]
  34. G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett. 20, 2258–2260 (1995). [CrossRef] [PubMed]
  35. P. Parsa, S. L. Jacques, and N. S. Nishioka, “Optical properties of rat liver between 350 and 2200nm,” Appl. Opt. 28, 2325–2330 (1989). [CrossRef] [PubMed]
  36. L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12, 014017 (2007). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited