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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 18 — Jun. 20, 2010
  • pp: 3538–3544

Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography

Peng Lee, Wanrong Gao, and Xianling Zhang  »View Author Affiliations


Applied Optics, Vol. 49, Issue 18, pp. 3538-3544 (2010)
http://dx.doi.org/10.1364/AO.49.003538


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Abstract

Tissue optical properties can be determined with optical coherence tomography (OCT) by fitting a model to the OCT signal. Using calibrated samples in the fixed focus geometry, the validity of the single-scattering and multiple-scattering models for both highly scattering and weakly scattering media (scattering coefficients μ s ranging from 1.25 to 25.11 mm 1 ) has been investigated. The results show that, with a proper correction for the confocal properties of the sample arm, both models are appropriate to extract the scattering coefficients of weakly scattering media. For highly scattering media, the multiple scattering should be taken into account, and the multiple-scattering model can provide higher accuracy. Finally, the scattering properties of in vitro rat liver and in vivo human skin are determined. The results are useful for quantitatively characterizing tissue scattering in biomedical research and clinical diagnosis.

© 2010 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(290.5820) Scattering : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Imaging Systems

History
Original Manuscript: March 2, 2010
Revised Manuscript: May 20, 2010
Manuscript Accepted: May 28, 2010
Published: June 16, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Peng Lee, Wanrong Gao, and Xianling Zhang, "Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography," Appl. Opt. 49, 3538-3544 (2010)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-49-18-3538

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