Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy
Applied Optics, Vol. 49, Issue 2, pp. 142-152 (2010)
http://dx.doi.org/10.1364/AO.49.000142
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Abstract
We report a probe-based portable and clinically compatible instrument for the spectral diagnosis of melanoma and nonmelanoma skin cancers. The instrument combines two modalities—diffuse reflectance and intrinsic fluorescence spectroscopy—to provide complementary information regarding tissue morphology, function, and biochemical composition. The instrument provides a good signal-to-noise ratio for the collected reflectance and laser-induced fluorescence spectra. Validation experiments on tissue phantoms over a physiologically relevant range of albedos (
© 2010 Optical Society of America
OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: June 3, 2009
Revised Manuscript: October 4, 2009
Manuscript Accepted: December 3, 2009
Published: January 7, 2010
Virtual Issues
Vol. 5, Iss. 3 Virtual Journal for Biomedical Optics
Citation
Narasimhan Rajaram, Timothy J. Aramil, Kelvin Lee, Jason S. Reichenberg, Tri H. Nguyen, and James W. Tunnell, "Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy," Appl. Opt. 49, 142-152 (2010)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-49-2-142
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