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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 23 — Aug. 10, 2010
  • pp: 4343–4354

Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies

Jiajia Ge, Sarah J. Erickson, and Anuradha Godavarty  »View Author Affiliations


Applied Optics, Vol. 49, Issue 23, pp. 4343-4354 (2010)
http://dx.doi.org/10.1364/AO.49.004343


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Abstract

A handheld-probe-based optical imager has recently been developed toward three-dimensional tomography. In this study, the improvement of target depth recovery was demonstrated using a multi-projection technique on large slab phantoms using 0.45 cc fluorescing target(s) (with 1 0 contrast ratio) of 1.5 to 2.5 cm deep. Tomographic results using single- and multi- (here dual) projection measurements (with and without a priori information of target location) were compared. In all experimental cases, the use of multi-projection measurements along with a priori information recovered target depth and location closer to their true values, demonstrating its applicability for clinical translation.

© 2010 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6960) Medical optics and biotechnology : Tomography
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 18, 2010
Revised Manuscript: July 7, 2010
Manuscript Accepted: July 7, 2010
Published: August 4, 2010

Virtual Issues
Vol. 5, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Jiajia Ge, Sarah J. Erickson, and Anuradha Godavarty, "Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies," Appl. Opt. 49, 4343-4354 (2010)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-49-23-4343

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