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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 27 — Sep. 20, 2010
  • pp: 5026–5031

Simple two-layer reflectance model for biological tissue applications: lower absorbing layer

George Zonios and Aikaterini Dimou  »View Author Affiliations


Applied Optics, Vol. 49, Issue 27, pp. 5026-5031 (2010)
http://dx.doi.org/10.1364/AO.49.005026


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Abstract

A simple two-layer tissue reflectance model is described. This work is a continuation of our investigations on modeling reflectance from two-layered tissues that we recently initiated. In the present article, we describe a variation of a two-layer model that assumes a lower absorbing and scattering layer and an upper scattering-only layer. This two-layer configuration is a realistic model for biological tissues in the visible and near-IR spectral ranges, where the upper layer may be an epithelial layer and the lower layer is a vascularized stroma layer. Application of the model yields estimates for tissue parameters, such as the thickness of the upper layer or the absorption properties of the lower layer. These parameters are of great interest for the noninvasive study of a wide range of epithelial biological tissues. The validity range and accuracy of the model are tested on tissue phantoms in both the forward and inverse modes of application.

© 2010 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 8, 2009
Revised Manuscript: July 11, 2010
Manuscript Accepted: August 12, 2010
Published: September 10, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Citation
George Zonios and Aikaterini Dimou, "Simple two-layer reflectance model for biological tissue applications: lower absorbing layer," Appl. Opt. 49, 5026-5031 (2010)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-49-27-5026


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