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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 29 — Oct. 10, 2010
  • pp: 5583–5591

Diffractive-optics-based sensor as a tool for detection of biocompatibility of titanium and titanium-doped hydrocarbon samples

Raimo Silvennoinen, Stanislav Hasoň, Vladimír Vetterl, Niko Penttinen, Martti Silvennoinen, Kari Myller, Pavlína Černochová, Sonia Bartáková, Patrik Prachár, and Ladislav Cvrček  »View Author Affiliations

Applied Optics, Vol. 49, Issue 29, pp. 5583-5591 (2010)

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Adsorption of the elongated human plasma fibrinogen (HPF) and globular human serum albumin molecules on a titanium-based surface is monitored by analyzing permittivity and optical roughness of protein-modified surfaces by using a diffractive optical element (DOE)-based sensor and variable angle spectro-ellipsometry (VASE). Both DOE and VASE confirmed that fibrinogen forms a thicker and more packed surface adlayer compared to a more porous and weakly adsorbed albumin adlayer. A linear relation of the permittivity ( ε ) and dielectric loss ( ε ) was found for some of the dry titanium-doped hydrocarbon (TDHC) surfaces with excellent HPF adsorption ability. We discuss some aspects of TDHC’s aging and its possible effects on fibrinogen adsorption.

© 2010 Optical Society of America

OCIS Codes
(050.1970) Diffraction and gratings : Diffractive optics
(170.1850) Medical optics and biotechnology : Dentistry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(240.5770) Optics at surfaces : Roughness
(240.2130) Optics at surfaces : Ellipsometry and polarimetry

ToC Category:
Instrumentation, Measurement, and Metrology

Original Manuscript: April 2, 2010
Revised Manuscript: August 4, 2010
Manuscript Accepted: August 28, 2010
Published: October 7, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Raimo Silvennoinen, Stanislav Hasoň, Vladimír Vetterl, Niko Penttinen, Martti Silvennoinen, Kari Myller, Pavlína Černochová, Sonia Bartáková, Patrik Prachár, and Ladislav Cvrček, "Diffractive-optics-based sensor as a tool for detection of biocompatibility of titanium and titanium-doped hydrocarbon samples," Appl. Opt. 49, 5583-5591 (2010)

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