OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 50, Iss. 10 — Apr. 1, 2011
  • pp: 1312–1322

Study of rotational dynamics of receptor-targeted contrast agents in cancerous and normal prostate tissues using time-resolved picosecond emission spectroscopy

Yang Pu, Wubao B. Wang, Samuel Achilefu, and R. R. Alfano  »View Author Affiliations


Applied Optics, Vol. 50, Issue 10, pp. 1312-1322 (2011)
http://dx.doi.org/10.1364/AO.50.001312


View Full Text Article

Enhanced HTML    Acrobat PDF (743 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We studied the time-resolved polarization-dependent fluorescence spectroscopy of receptor-targeted contrast agents (Cybesin and Cytate) bound with prostate cancer cells in prostate tissue. An analytical model dealing with highly viscous tissue media was developed and used to investigate the rotation times and fluorescence anisotropies of the receptor-targeted contrast agents in prostate tissue. The differences of rotation times and fluorescence anisotropies were observed for Cybesin (Cytate) in cancerous and normal prostate tissues, which reflect changes of the microstructures of cancerous and normal tissues and their different bound affinity with contrast agents. The preferential uptake of Cytate (Cybesin) in cancerous tissue was used to image and distinguish cancerous tissue areas from normal tissue areas. The fluorescence polarization difference imaging technique was used to enhance the image contrast between the cancerous and normal tissue areas. This research may help to introduce a new optical approach and criteria for prostate cancer detection.

© 2011 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6930) Medical optics and biotechnology : Tissue
(300.6500) Spectroscopy : Spectroscopy, time-resolved

ToC Category:
Spectroscopy

History
Original Manuscript: June 28, 2010
Revised Manuscript: January 12, 2011
Manuscript Accepted: January 6, 2011
Published: March 24, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Yang Pu, Wubao B. Wang, Samuel Achilefu, and R. R. Alfano, "Study of rotational dynamics of receptor-targeted contrast agents in cancerous and normal prostate tissues using time-resolved picosecond emission spectroscopy," Appl. Opt. 50, 1312-1322 (2011)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-50-10-1312

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you are accessing the full text through a member bundle, please use the Enhanced HTML link to gain access to the citation lists and other restricted features. Note that accessing both the PDF and HTML versions of an article will count as only one download against your account.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you are accessing the full text through a member bundle, please use the Enhanced HTML link to gain access to the citation lists and other restricted features. Note that accessing both the PDF and HTML versions of an article will count as only one download against your account.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you wish to use one of your free member downloads to view the figures, click "Enhanced HTML" above and access the figures from the article itself or from the navigation tab.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you are accessing the full text through a member bundle, please use the Enhanced HTML link to gain access to the citation lists and other restricted features. Note that accessing both the PDF and HTML versions of an article will count as only one download against your account.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited