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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 50, Iss. 28 — Oct. 1, 2011
  • pp: 5397–5407

Early-photon fluorescence tomography of a heterogeneous mouse model with the telegraph equation

Bin Zhang, Xu Cao, Fei Liu, Xin Liu, Xin Wang, and Jing Bai  »View Author Affiliations

Applied Optics, Vol. 50, Issue 28, pp. 5397-5407 (2011)

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In this study, we investigate the performance of early-photon fluorescence tomography based on a heterogeneous mouse model. The telegraph equation is used to accurately describe the propagation of light in tissues at short times. The optimal time gate for early photons is determined by singular value analysis at first. Then, fluorescent targets located in different organs of the mouse model are investigated. The simulation results demonstrate that the reconstructed tomographic images based on early photons yield improvement in spatial resolution and quantification than the quasi-CW measurements. Meanwhile, compared with the homogeneous model, the use of the heterogeneous model can improve the accuracy of fluorescence distribution and quantification in early-photon fluorescence tomography.

© 2011 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 11, 2011
Revised Manuscript: July 24, 2011
Manuscript Accepted: August 8, 2011
Published: September 22, 2011

Virtual Issues
Vol. 6, Iss. 11 Virtual Journal for Biomedical Optics

Bin Zhang, Xu Cao, Fei Liu, Xin Liu, Xin Wang, and Jing Bai, "Early-photon fluorescence tomography of a heterogeneous mouse model with the telegraph equation," Appl. Opt. 50, 5397-5407 (2011)

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