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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 51, Iss. 10 — Apr. 1, 2012
  • pp: 1436–1445

Variations in signal intensity with periodical temperature changes in vivo in rat brain: analysis using wide-field optical coherence tomography

Manabu Sato, Daisuke Nomura, Tetsushi Kitano, Takashi Tsunenari, and Izumi Nishidate  »View Author Affiliations


Applied Optics, Vol. 51, Issue 10, pp. 1436-1445 (2012)
http://dx.doi.org/10.1364/AO.51.001436


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Abstract

In a previous study, we reported measurements of three-dimensional (3D) optical coherence tomography (OCT) images through a thinned skull by reducing temperatures from 28 °C to 18 °C in vivo in the rat brain to show negative correlation coefficients (CCs) between ratios of signal intensity (RSI) and temperature for applications to monitoring brain viability. In this study, using the same OCT system, we measured 3D OCT images of the rat brain by periodically changing tissue temperatures from 20 °C to 32 °C in vivo. In the evaluation of CCs among RSI, temperature, and heart rate, the largest number of periods was four, and the longest measurement time was 570 min. Averaged CCs between RSI and temperature, and between RSI and heart rate, were 0.42 to 0.50 and 0.48 to 0.64, respectively. RSI reversibly changed subsequent variations of temperatures and finally increased rapidly just before cardiac arrest. These results indicate that RSI could correspond to decreases in viability because of local ischemia and recovery.

© 2012 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 8, 2011
Revised Manuscript: November 2, 2011
Manuscript Accepted: January 10, 2012
Published: March 21, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Manabu Sato, Daisuke Nomura, Tetsushi Kitano, Takashi Tsunenari, and Izumi Nishidate, "Variations in signal intensity with periodical temperature changes in vivo in rat brain: analysis using wide-field optical coherence tomography," Appl. Opt. 51, 1436-1445 (2012)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-51-10-1436

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