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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 51, Iss. 10 — Apr. 1, 2012
  • pp: C32–C37

Optical analysis of adsorption sensitivity of titanium, Ti-6Al-4V, and Ti-35Nb-6Ta

Niko Penttinen, Stanislav Hasoň, Jiři Vaněk, and Raimo Silvennoinen  »View Author Affiliations

Applied Optics, Vol. 51, Issue 10, pp. C32-C37 (2012)

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Here we report the optical analysis of protein adsorption sensitivity of titanium (Ti), Ti6Al4V, and Ti35Nb6Ta. The optical sensor used was a diffractive optical element based sensor, which analyzes magnitude and coherence of probe beam reflected from the measured surfaces. Also, the roughness and other necessary parameters were taken into account on the final verdict. The material Ti35Nb6Ta showed positive initial reaction to the human plasma fibrinogen, which was the protein used. The Ti35Nb6Ta was observed to be more active than the grade 2 titanium.

© 2012 Optical Society of America

OCIS Codes
(050.1970) Diffraction and gratings : Diffractive optics
(160.3900) Materials : Metals
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(160.1435) Materials : Biomaterials

Original Manuscript: November 30, 2011
Revised Manuscript: February 10, 2012
Manuscript Accepted: February 13, 2012
Published: March 19, 2012

Niko Penttinen, Stanislav Hasoň, Jiři Vaněk, and Raimo Silvennoinen, "Optical analysis of adsorption sensitivity of titanium, Ti-6Al-4V, and Ti-35Nb-6Ta," Appl. Opt. 51, C32-C37 (2012)

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  1. C. J. Wilson, R. E. Clegg, D. I. Leavesley, and M. J. Pearcy, “Mediation of biomaterial-cell interactions by adsorbed proteins: A review,” Tissue Eng. 11, 1–18 (2005).
  2. R. Gorman, G. Stoner, and A. Catlin, “The adsorption of fibrinogen. An electron microscope study,” J. Phys. Chem. 75, 2103–2107 (1971). [CrossRef]
  3. D. Kim, H. Blanch, and C. Radke, “Direct imaging of lysozyme adsorption onto mica by atomic force microscopy,” Langmuir 18, 5841–5850 (2002). [CrossRef]
  4. D. Cullen and C. Lowe, “AFM studies of protein adsorption. 1. time-resolved protein adsorption to highly oriented pyrolytic-graphite,” J. Colloid Interf. Sci. 166, 102–108 (1994).
  5. T. Ta, M. Sykes, and M. McDermott, “Real-time observation of plasma protein film formation on well-defined surfaces with scanning force microscopy,” Langmuir 14, 2435–2443 (1998). [CrossRef]
  6. S. G. Thakurta and A. Subramanian, “Evaluation of in situ albumin binding surfaces: a study of protein adsorption and platelet adhesion,” J. Mater. Sci. 22, 1–13 (2010).
  7. N. Penttinen, S. Hason, M. Silvennoinen, S. Bartakova, P. Prachar, J. Vanek, L. Cvrcek, V. Vetterl, and R. Silvennoinen, “Coherence and magnitude of optical signals from TiAlV and TiNbTa surfaces: Study on adsorption properties,” presented at the 10th International Conference, Correlation Optics, Chernivtsi, Ukraine, 12–16Sept.2011.
  8. N. Penttinen, S. Hason, L. Joska, L. Cvrcek, and R. Silvennoinen, “On the analysis of optical signals from Ti35Nb6Ta and Ti6Al4V surfaces,” Proc. SPIE 8338, 83380Q (2011). [CrossRef]
  9. C. E. Hall and H. S. Slayter, “The fibrinogen molecule: Its size, shape, and mode of polymerization,” J. Biophys. Biochem. Cytol. 5, 11–18 (1959).
  10. N. Penttinen, S. Hason, M. Silvennoinen, L. Joska, and R. Silvennoinen, “Comparison of optical models and signals from XPS and VASE characterized titanium after PBS immersion,” Opt. Commun. 285, 965–968 (2012).
  11. S. Lousinian and S. Logothetidis, “In-situ and real-time protein adsorption study by spectroscopic ellipsometry,” Thin Solid Films 516, 8002–8008 (2008). [CrossRef]
  12. M. Malmsten, “Ellipsometry studies of protein adsorption at lipid surfaces,” J. Colloid Interf. Sci. 168, 247–254(1994).
  13. M. Malmsten, “Ellipsometry studies of fibronectin adsorption,” Coll. Surfaces B 3, 371–381 (1995).
  14. R. Silvennoinen, K.-E. Peiponen, and K. Myller, Specular Gloss (Elsevier, 2008).
  15. D. Deligianni, N. Katsala, S. Ladas, D. Sotiropoulou, J. Amedee, and Y. Missirlis, “Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption,” Biomaterials 22, 1241–1251 (2001). [CrossRef]
  16. M. Niinomi, “Mechanical properties of biomedical titanium alloys,” Mater. Sci. Eng. A 243, 231–236 (1998).
  17. R. Silvennoinen, S. Hason, V. Vetterl, N. Penttinen, M. Silvennoinen, K. Myller, P. Cernochova, S. Bartakova, P. Prachar, and L. Cvrcek, “Diffractive-optics-based sensor as a tool for detection of biocompatibility of titanium and titanium-doped hydrocarbon samples,” Appl. Opt. 49, 5583–5591 (2010). [CrossRef]
  18. R. Silvennoinen, V. Vetterl, S. Hason, H. Tuononen, M. Silvennoinen, K. Myller, L. Cvrcek, J. Vanek, and P. Prachar, “Sensing of human plasma fibrinogen on polished, chemically etched and carbon treated titanium surfaces by diffractive optical element based sensor,” Opt. Express 16, 10130–10140 (2008). [CrossRef]
  19. R. Silvennoinen, N. Penttinen, M. Silvennoinen, S. Hason, V. Vetterl, S. Bartakova, P. Prachar, J. Vanek, and V. Brezina, Optical Detection of Protein Adsorption on Doped Titanium Surface (InTech, 2011), pp. 173–190.
  20. N. Penttinen, M. Silvennoinen, S. Hason, and R. Silvennoinen, “Directional sensing of protein adsorption on titanium with a light-induced periodic structure,” J. Phys. Chem. C 115, 12951–12959 (2011). [CrossRef]

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