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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 51, Iss. 14 — May. 10, 2012
  • pp: 2713–2721

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Rebecca M. Smith, Adam J. Black, Saalini S. Velamakanni, Taner Akkin, and Elena G. Tolkacheva  »View Author Affiliations


Applied Optics, Vol. 51, Issue 14, pp. 2713-2721 (2012)
http://dx.doi.org/10.1364/AO.51.002713


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Abstract

Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n=5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These “fingers” may play an important role in the initiation and maintenance of ventricular arrhythmias.

© 2012 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.5380) Medical optics and biotechnology : Physiology

ToC Category:
Imaging Systems

History
Original Manuscript: October 27, 2011
Revised Manuscript: January 24, 2012
Manuscript Accepted: March 14, 2012
Published: May 10, 2012

Virtual Issues
Vol. 7, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Rebecca M. Smith, Adam J. Black, Saalini S. Velamakanni, Taner Akkin, and Elena G. Tolkacheva, "Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart," Appl. Opt. 51, 2713-2721 (2012)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-51-14-2713

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Supplementary Material


» Media 1: AVI (50845 KB)     
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