A novel handheld probe based on a microelectromechanical systems (MEMS) scanning mirror for three-dimensional (3D) fluorescence molecular tomography (FMT) is described. The miniaturized probe consists of a MEMS mirror for delivering an excitation light beam to multiple preselected points at the tissue surface and an optical fiber array for collecting the fluorescent emission light from the tissue. Several phantom experiments based on indocyanine green, an FDA approved near-infrared (NIR) fluorescent dye, were conducted to assess the imaging ability of this device. Tumor-bearing mice with systematically injected tumor-targeted NIR fluorescent probes were scanned to further demonstrate the ability of this MEMS-based FMT for imaging small animals.
© 2012 Optical Society of America
Medical Optics and Biotechnology
Original Manuscript: April 20, 2012
Manuscript Accepted: May 12, 2012
Published: July 3, 2012
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics
Bin He, Lei Xi, Sean R. Samuelson, Huikai Xie, Lily Yang, and Huabei Jiang, "Microelectromechanical systems scanning-mirror-based handheld probe for fluorescence molecular tomography," Appl. Opt. 51, 4678-4683 (2012)