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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 51, Iss. 36 — Dec. 20, 2012
  • pp: 8656–8668

Time-domain fluorescence-guided diffuse optical tomography based on the third-order simplified harmonics approximation

Wenjuan Ma, Wei Zhang, Xi Yi, Jiao Li, Linhui Wu, Xin Wang, Limin Zhang, Zhongxing Zhou, Huijuan Zhao, and Feng Gao  »View Author Affiliations

Applied Optics, Vol. 51, Issue 36, pp. 8656-8668 (2012)

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Extensive efforts have been made to integrate diffuse optical tomography (DOT) with other imaging modalities, such as magnetic-resonance imaging and x-ray computerized tomography, for its performance improvement. However, the experimental apparatus is in general intricate and costly due to adoption of the physically distinct radiation regimes. In this study, a time-domain fluorescence-guided DOT methodology that incorporates a priori localization information provided by diffuse fluorescence tomography (DFT) is investigated in an attempt to optimize recovery of the optical property distributions. The methodology is based on a specifically designed multichannel time-correlated single-photon-counting DOT/DFT system as well as a featured-data image reconstruction scheme that is developed within the framework of the generalized pulse spectrum technique and employs the third-order simplified harmonics approximation to the radiative transfer equation as the forward model. We have validated the methodology using phantom experiments and demonstrated that, with the guidance of fluorescence a priori, the quantitativeness and spatial resolution of the recovered optical target can be considerably improved in terms of the absorption and scattering images.

© 2012 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 6, 2012
Revised Manuscript: September 22, 2012
Manuscript Accepted: November 15, 2012
Published: December 17, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Wenjuan Ma, Wei Zhang, Xi Yi, Jiao Li, Linhui Wu, Xin Wang, Limin Zhang, Zhongxing Zhou, Huijuan Zhao, and Feng Gao, "Time-domain fluorescence-guided diffuse optical tomography based on the third-order simplified harmonics approximation," Appl. Opt. 51, 8656-8668 (2012)

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