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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 52, Iss. 12 — Apr. 20, 2013
  • pp: 2739–2749

Study of the effect of mechanical pressure on determination of position and size of tumor in biological phantoms

Mohammad Ali Ansari, Mohsen Erfanzadeh, Saeid Alikhani, and Ezeddin Mohajerani  »View Author Affiliations


Applied Optics, Vol. 52, Issue 12, pp. 2739-2749 (2013)
http://dx.doi.org/10.1364/AO.52.002739


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Abstract

Diffuse optical tomography (DOT) is an emerging oncological imaging modality that is based on a near-infrared optical technique. DOT provides the spatial volume and depth of tumors by determination of optical properties of biological tissues, such as the absorption and scattering coefficients. During a DOT, the optical fibers are kept in contact with biological tissues that introduce a certain amount of pressure on the local biological tissue. Due to this pressure, the shape of the organ, for instance a breast, deforms. Moreover, this pressure could influence the intrinsic characteristics of the biological tissue. Therefore, pressure can be an important parameter in DOT. In this paper, the effects of pressure on the determination of the size and position of a tumor in biological phantoms are studied. To do so, tissue-like phantoms that are made of intralipid, Indian ink, and agar are constructed. Defects with optical properties similar to those of tumors are placed inside the phantoms. Then various values of pressure are applied to the phantoms. Subsequently, the optical properties of phantoms as well as the position and size of the tumor are reconstructed by inverse models based on the boundary integral method. The variations of reconstructed data induced by pressure are studied. The results demonstrate that pressure causes an increase in the scattering coefficient.

© 2013 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 11, 2012
Revised Manuscript: January 7, 2013
Manuscript Accepted: March 6, 2013
Published: April 17, 2013

Virtual Issues
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Mohammad Ali Ansari, Mohsen Erfanzadeh, Saeid Alikhani, and Ezeddin Mohajerani, "Study of the effect of mechanical pressure on determination of position and size of tumor in biological phantoms," Appl. Opt. 52, 2739-2749 (2013)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-52-12-2739

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