Ultrasound modulated optical tomography (USMOT) can image the optical properties of a scattering medium at a spatial resolution approaching that of ultrasound (US). A lock-in parallel speckle detection technique is proposed to detect pulsed US modulated light using a multipixel detector. The frequency components of the pass band match those of the US pulse train and provide efficient detection. The modulation depth is extracted by taking the difference between a pair of speckle patterns modulated by a pair of phase-inversed US bursts. Modification to pulse inversion mode enables the second harmonic US modulation due to nonlinear US propagation to be detected.
© 2013 Optical Society of America
Original Manuscript: May 31, 2013
Revised Manuscript: May 31, 2013
Manuscript Accepted: June 1, 2013
Published: June 28, 2013
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics
H. Ruan, M. L. Mather, and S. P. Morgan, "Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection," Appl. Opt. 52, 4755-4762 (2013)