Abstract

In the course of operating process equipment in the pharmaceutical industry, it is necessary to assure that all product contact surfaces of process equipment contain a minimum amount of residue. The residue may be another product remaining from a previous operation, an excipient, or a "nonformulation" type of material. This report discusses the determination of hydrocarbons, in the form of lubricating greases, on the product contact surface of various tablet presses by use of FT-IR spectroscopy. The FT-IR spectroscopic method provides for both identification and quantitation of the lubricant and was suggested by an EPA method.

Recent applications of FT-IR spectroscopy to polymer systems

J. L. Koenig and M. K. Antoon
Appl. Opt. 17(9) 1374-1385 (1978)

Density-dependent determination of scattering properties of pharmaceutical tablets using coherent backscattering spectroscopy

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Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges

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Comprehensive study of solid pharmaceutical tablets in visible, near infrared (NIR), and longwave infrared (LWIR) spectral regions using a rapid simultaneous ultraviolet/visible/NIR (UVN) + LWIR laser-induced breakdown spectroscopy linear arrays detection system and a fast acousto-optic tunable filter NIR spectrometer

Clayton S.C Yang, Feng Jin, Siva R. Swaminathan, Sita Patel, Evan D. Ramer, Sudhir B. Trivedi, Ei E. Brown, Uwe Hommerich, and Alan C. Samuels
Opt. Express 25(22) 26885-26897 (2017)

Authentication of gold nanoparticle encoded pharmaceutical tablets using polarimetric signatures

Artur Carnicer, Oriol Arteaga, Josep M. Suñé-Negre, and Bahram Javidi
Opt. Lett. 41(19) 4507-4510 (2016)