Abstract

Fundamental aspects regarding the use of time-of-flight secondary-ion mass spectrometry (TOF-SIMS) as a quantitative tool for the analysis of organic compounds are reported. The following factors are discussed: (1) the use of Poisson's law to correct for dead-time in single-ion data collection; (2) practical considerations concerning the analysis of "real world" samples; and (3) the effect of the etching process on the reproducibility of the intensity ratio (analyte/internal standard) of Ag-cationized species. To evaluate the importance of these factors, we used cocaine and cyclosporin A (CsA) as analytes because they show protonated and Ag-cationized species, respectively, in their SIMS spectra. Correction for detector dead-time using Poisson's law of single-ion counting expanded the dynamic range for cocaine by ~ 2 orders of magnitude. For analyses requiring only a small dynamic range (i.e., CsA), the correction improved the % RSD of the slope from 2.43 to 0.87%. The maximum secondary-ion (SI) yield of CsA (Ag-eationized species) occurs at a CsA concentration ~3 orders of magnitude higher than the therapeutic levels in blood (25-2000 ng/mL). It is discussed how this problem should be addressed. Analysis of variance (ANOVA) indicates that Ag substrates must be etched under identical conditions to obtain quantitative results when species requiring cationization are being analyzed.

Composition of nanoparticles in optical fibers by Secondary Ion Mass Spectrometry

Wilfried Blanc, Christelle Guillermier, and Bernard Dussardier
Opt. Mater. Express 2(11) 1504-1510 (2012)

Secondary-ion mass spectroscopy characterization of proton-exchanged LiNbO₃ waveguides

N. A. Sanford and W. C. Robinson
Opt. Lett. 10(4) 190-192 (1985)

Chemical ionization Fourier transform mass spectrometry of chemical warfare agent simulants using laser-produced metal ions

Chih-Cong Chou and S. Randolph Long
Appl. Opt. 29(33) 4981-4986 (1990)

Mass spectrometry of ion-induced water clusters: an explanation of the infrared continuum absorption

Hugh R. Carlon and Charles S. Harden
Appl. Opt. 19(11) 1776-1786 (1980)

Measurement of the isotope selectivity of the strontium magneto-optical trap by a time-of-flight mass spectrometer

Kwang-Hoon Ko, You-Kyoung Lim, Do-Young Jeong, Hyunmin Park, Taek-Soo Kim, Gwon Lim, and Hyung Ki Cha
J. Opt. Soc. Am. B 23(12) 2465-2469 (2006)