Abstract

We have demonstrated the use of surface-enhanced Raman scattering (SERS) spectroscopy for the detection of the phenylalkylamines amphetamine and methamphetamine. This work can be viewed as the first phase of development toward a one-step drug detection method with a selective reactive coating on a SERS substrate. This work involves a fairly complicated coupling reaction prior to surface derivatization. Future efforts will be directed at creating a reactive coating directly on the surface. The amines were derivatized by a coupling reaction with 2-mercaptonicotinic acid (2-MNA) with the use of dicyclohexylcarbodiimide (DCC) as the coupling reagent to form the amide compounds AMNA [N-(1-methyl-2-phenylethyl)2-mercaptopyridine-3-carboxamide] and MMNA [N-methyl-N-(1-methyl-2-phenylethyl)-2-mercaptopyridine-3-carboxamide]. The amides were qualitatively identified from SERS spectra. Quantification of the amides was accomplished by adding the internal standard pentachlorothiophenol (PCTP) and measuring the intensity of Raman bands of the analyte relative to a Raman band of the internal standard. Calibration curves were plotted of the relative peak intensity ratios as a function of analyte concentration. Detection limits of 19 ppm and 17 ppm were found for amphetamine/2-MNA (AMNA) amide and methamphetamine/2-MNA (MMNA) amide, respectively.

Surface-enhanced Raman scattering of trace Hg²⁺ on a 4-mercaptobenzoic acid-modified nanoporous Au substrate

Xiangfa Kong, Chaohui Cheng, Qifan Wang, Mianwu Meng, Chaoshu Chen, Xiujian Wang, Siyu Huang, and Weixin Gan
Opt. Mater. Express 11(9) 3015-3022 (2021)

Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid

Yang Li, Haolin Chen, Yanxian Guo, Kangkang Wang, Yue Zhang, Peilin Lan, Jinhao Guo, Wen Zhang, Huiqing Zhong, Zhouyi Guo, Zhengfei Zhuang, and Zhiming Liu
Photon. Res. 9(6) 1039-1047 (2021)

Leukemia cells detection based on electroporation assisted surface-enhanced Raman scattering

Yun Yu, Juqiang Lin, Duo Lin, Shangyuan Feng, Weiwei Chen, Zufang Huang, Hao Huang, and Rong Chen
Biomed. Opt. Express 8(9) 4108-4121 (2017)

Sensitive surface enhanced Raman scattering multiplexed detection of matrix metalloproteinase 2 and 7 cancer markers

Tianxun Gong, Kien Voon Kong, Douglas Goh, Malini Olivo, and Ken-Tye Yong
Biomed. Opt. Express 6(6) 2076-2087 (2015)

Surface-enhanced Raman scattering biosensor for DNA detection on nanoparticle island substrates

Wu Yuan, Ho Pui Ho, Rebecca K. Y. Lee, and Siu Kai Kong
Appl. Opt. 48(22) 4329-4337 (2009)