OSA's Digital Library

Applied Spectroscopy

Applied Spectroscopy

| PUBLISHED BY SAS — AVAILABLE FROM SAS AND OSA

  • Vol. 60, Iss. 10 — Oct. 1, 2006
  • pp: 1127–1133

Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma

Vincent P. Wallace, Anthony J. Fitzgerald, Emma Pickwell, Richard J. Pye, Philip F. Taday, Niamh Flanagan, and Thomas Ha

Applied Spectroscopy, Vol. 60, Issue 10, pp. 1127-1133 (2006)


View Full Text Article

Acrobat PDF (346 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Good contrast is seen between normal tissue and regions of tumor in terahertz pulsed imaging of basal cell carcinoma (BCC). To date, the source of contrast at terahertz frequencies is not well understood. In this paper we present results of a spectroscopy study comparing the terahertz properties (absorption coefficient and refractive index) of excised normal human skin and BCC. Both the absorption coefficient and refractive index were higher for skin that contained BCC. The difference was statistically significant over the range 0.2 to 2.0 THz (6.6 cm−1 to 66.6 cm−1) for absorption coefficient and 0.25 to 0.90 THz (8.3 cm−1 to 30 cm−1) for refractive index. The maximum difference for absorption was at 0.5 THz(16.7 cm−1). These changes are consistent with higher water content. These results account for the contrast seen in terahertz images of BCC and explain why parameters relating to the reflected terahertz pulse provide information about the lateral spread of the tumor. Knowing the properties of the tissue over the terahertz frequency range will enable the use of mathematical models to improve understanding of the terahertz response of normal and diseased tissue.

Citation
Vincent P. Wallace, Anthony J. Fitzgerald, Emma Pickwell, Richard J. Pye, Philip F. Taday, Niamh Flanagan, and Thomas Ha, "Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma," Appl. Spectrosc. 60, 1127-1133 (2006)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-60-10-1127

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited