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Applied Spectroscopy

Applied Spectroscopy

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  • Vol. 60, Iss. 6 — Jun. 1, 2006
  • pp: 663–671

Coded Aperture Raman Spectroscopy for Quantitative Measurements of Ethanol in a Tissue Phantom

S. T. McCain, M. E. Gehm, Y. Wang, N. P. Pitsianis, and D. J. Brady

Applied Spectroscopy, Vol. 60, Issue 6, pp. 663-671 (2006)


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Abstract

Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r2 > 0.98. Leave-one-out cross-validation demonstrates prediction errors of, <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.

Citation
S. T. McCain, M. E. Gehm, Y. Wang, N. P. Pitsianis, and D. J. Brady, "Coded Aperture Raman Spectroscopy for Quantitative Measurements of Ethanol in a Tissue Phantom," Appl. Spectrosc. 60, 663-671 (2006)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-60-6-663


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