Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 64,
  • Issue 8,
  • pp. 949-955
  • (2010)

Rapid Simultaneous Determination of Four Non-steroidal Anti-inflammatory Drugs by Means of Derivative Nonlinear Variable-Angle Synchronous Fluorescence Spectrometry

Not Accessible

Your library or personal account may give you access

Abstract

A rapid, simple, and inexpensive spectrofluorimetric method has been proposed for the simultaneous quantification of diflunisal, salicylic acid, fenoprofen, and 6-methoxy-2-naphthylacetic acid (6MNA). First-derivative nonlinear variable-angle synchronous fluorescence spectrometry has been developed to improve the selectivity of fluorescence measurements without loss of sensitivity. It allows the simultaneous determination of different substances in a mixture from a single spectrum based on a single scan. The analyses were performed in an ethanol–water (70%) medium at a pH of 9.2, adjusted by using ammonium/ammonia (0.5 M) as a buffer solution. The linear concentration ranges are 30.0–100.0, 100.0–600.0, 50.0–150.0, and 30.0–100.0 ng/mL for salicylic acid, fenoprofen, diflunisal, and 6-methoxy-2-naphthylacetic acid, respectively, at λ<sub>ex</sub>/λ<sub>em</sub> = 281.1/423.6, 241.2/301.2, 284.1/403.8, and 268.7/339.6 nm, respectively. Analytical parameters of the proposed method were calculated according to the error propagation theory. The sensitivity, repeatability, reproducibility, and limits of detection achieved with the proposed method are adequate for the determination of these anti-inflammatory drugs.

PDF Article
More Like This
Metal-printing directly defined polymer optical waveguide sensors for detecting effective anti-inflammatory concentrations of peimine as fritillaria alkaloid drugs

P. F. Yi, P. Shen, Y. Zheng, C. M. Chen, L. G. Liang, J. H. Wang, L. C. Shang Guan, and D. M. Zhang
Opt. Mater. Express 7(7) 2230-2241 (2017)

Changes in the luminescence between dried and wet bacillus spores

Joseph Kunnil, Barry Swartz, and Lou Reinisch
Appl. Opt. 43(28) 5404-5409 (2004)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved