Enhanced Mid-Infrared Chemical Imaging (IRCI) Detection of DNA Microarrays
Applied Spectroscopy, Vol. 66, Issue 12, pp. 1480-1486 (2012)
Acrobat PDF (2304 KB)
Abstract
We report on the optimization of a recently proposed mid-infrared chemical imaging (IRCI) detection method for the analysis of DNA microarrays. The improved protocol allowed for a ten-fold reduction in the time needed to generate a mosaic image of an entire microarray and the production of IR images with high contrast that would facilitate data analysis and interpretation. Advantages of using this protocol were evaluated by applying it to the analysis of four virulence genes in the genomes of 19 strains of the food bacterial pathogen Yersinia enterocolitica.
Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Brianna Schoen, Magdi M. Mossoba, Vladimir Chizhikov, Anis Rashid, Karen Martinez-Diaz, and Sufian F. Al-Khaldi, "Enhanced Mid-Infrared Chemical Imaging (IRCI) Detection of DNA Microarrays," Appl. Spectrosc. 66, 1480-1486 (2012)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-66-12-1480
You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
« Previous Article | Next Article »
OSA is a member of 