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Applied Spectroscopy

Applied Spectroscopy

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  • Vol. 67, Iss. 8 — Aug. 1, 2013
  • pp: 973–984

Sequentially Shifted Excitation Raman Spectroscopy: Novel Algorithm and Instrumentation for Fluorescence-Free Raman Spectroscopy in Spectral Space

John B. Cooper, Mohamed Abdelkader, and Kent L. Wise

Applied Spectroscopy, Vol. 67, Issue 8, pp. 973-984 (2013)


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Abstract

A novel Raman spectrometer is presented in a handheld format. The spectrometer utilizes a temperature-controlled, distributed Bragg reflector diode laser, which allows the instrument to operate in a sequentially shifted excitation mode to eliminate fluorescence backgrounds, fixed pattern noise, and room lights, while keeping the Raman data in true spectral space. The cost-efficient design of the instrument allows rapid acquisition of shifted excitation data with a shift time penalty of less than 2 s. The Raman data are extracted from the shifted excitation spectra using a novel algorithm that is typically three orders of magnitude faster than conventional shifted-excitation algorithms operating in spectral space. The superiority of the instrument and algorithm in terms of background removal and signal-to-noise ratio is demonstrated by comparison to FT-Raman, standard deviation spectra, shifted excitation Raman difference spectroscopy (SERDS), and conventional multiple-shift excitation methods.

Virtual Issues
Vol. 8, Iss. 9 Virtual Journal for Biomedical Optics

Citation
John B. Cooper, Mohamed Abdelkader, and Kent L. Wise, "Sequentially Shifted Excitation Raman Spectroscopy: Novel Algorithm and Instrumentation for Fluorescence-Free Raman Spectroscopy in Spectral Space," Appl. Spectrosc. 67, 973-984 (2013)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-67-8-973

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