Abstract

The Battelle Biological Spectroscopy Facility is currently studying the adsorption of blood proteins onto various surfaces using the combination of Fourier transform infrared spectroscopy (FT-IR) and attenuated total reflectance (ATR) optics. We have advanced our capabilities to study this phenomenon to the point where useful infrared spectra are obtained at 0.8-s intervals. This high-time resolution is helping to probe more accurately these important blood-surface interactions.

Recent applications of FT-IR spectroscopy to polymer systems

J. L. Koenig and M. K. Antoon
Appl. Opt. 17(9) 1374-1385 (1978)

Fiber-optic evanescent-wave spectroscopy for fast multicomponent analysis of human blood

Ronit Simhi, Yaron Gotshal, David Bunimovich, Ben-Ami Sela, and Abraham Katzir
Appl. Opt. 35(19) 3421-3425 (1996)

Total internal reflection ellipsometry: ultrahigh sensitivity for protein adsorption on metal surfaces

Michal Poksinski and Hans Arwin
Opt. Lett. 32(10) 1308-1310 (2007)

Use of attenuated total reflectance Fourier transform infrared spectroscopy to monitor the development of lipid aggregate structures

Mateo R. Hernandez, Elyse N. Towns, Terry C. Ng, Brian C. Walsh, Richard Osibanjo, Atul N. Parikh, and Donald P. Land
Appl. Opt. 51(15) 2842-2846 (2012)

Shift of whispering-gallery modes in microspheres by protein adsorption

S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, and F. Vollmer
Opt. Lett. 28(4) 272-274 (2003)