OSA's Digital Library

Applied Spectroscopy

Applied Spectroscopy

| PUBLISHED BY SAS — AVAILABLE FROM SAS AND OSA

  • Vol. 40, Iss. 4 — May. 1, 1986
  • pp: 538–542

Carbon13 NMR of Z- and E-Doxepin Hydrochloride

Dorothy K. Wyatt, Nina M. Roscher, and Lee T. Grady

Applied Spectroscopy, Vol. 40, Issue 4, pp. 538-542 (1986)


View Full Text Article

Acrobat PDF (496 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Carbon13 chemical shift assignments are reported for Z- and E-doxepin hydrochloride [Z- and E-N,N,-dimethyl-dibenz[b,e]oxepin-delta-11(6H)], gamma-propylamine hydrochloride, and related model compounds. Doxepin hydrochloride, a mixture of approximately 85% E- and 15% Z-isomer is of clinical importance as an antidepressant drug. Previous proton NMR studies indicated that the dibenz(b,e,)oxepin ring exists in two conformations. This study indicates that one conformation may be favored for each isomer with alkylamino olefinic substituent orientation above the most adjacent aromatic ring. Homo- and heteronuclear shift-correlated 2D NMR, selective INEPT, selective and off-resonance decoupling, and inversion-recovery (T1) experiments as well as model compound comparisons were used in assignments.

Citation
Dorothy K. Wyatt, Nina M. Roscher, and Lee T. Grady, "Carbon13 NMR of Z- and E-Doxepin Hydrochloride," Appl. Spectrosc. 40, 538-542 (1986)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-40-4-538


Sort:  Journal  |  Reset

References

References are not available for this paper.

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited