Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 41,
  • Issue 4,
  • pp. 597-605
  • (1987)

Raman Spectroscopic Study of Cataract Formation: Emory Mouse Cataract

Not Accessible

Your library or personal account may give you access

Abstract

Raman spectra of Emory mouse lenses at various stages of cataract formation have been measured and compared with those of normal lenses from ICR-strain mice. The relative intensity of an OH stretching mode of lens water was considerably stronger for the Emory mouse lenses, even in a precataractous stage, suggesting that lens hydration is deeply implicated in the initiation of Emory mouse cataract. The rate of 2SH → S-S conversion, estimated from the intensity decrease of a SH stretching mode, was similar between the Emory and ICR-strain mouse lenses, Accordingly, it seems unlikely that the conversion is a predominant factor for forming large protein aggregates which lead to lens opacification. A significant change was observed for the intensity ratio of a tyrosine doublet near 840 cm<sup>−1</sup> during the cataract development, suggesting that the strength of the hydrogen bonding of some tyrosine residues alters upon the formation of the large protein aggregates. Comparison of the Raman spectral changes observed for Emory mouse cataract with those for normal lens aging and other cataract formation leads us to the conclusion that the microenvironmental change of tyrosine residues is only one common specific feature for lens opacification.

PDF Article
More Like This
Investigation of the scattering and attenuation properties of cataracts formed in mouse eyes with 1060-nm and 1310-nm swept-source optical coherence tomography

Pablo Eugui, Conrad W. Merkle, Johanna Gesperger, Antonia Lichtenegger, and Bernhard Baumann
Biomed. Opt. Express 12(10) 6391-6406 (2021)

Experimental study of the mechanisms leading to the formation of glistenings in intraocular lenses by Raman spectroscopy

Giulia Rusciano, Angela Capaccio, Giuseppe Pesce, and Antonio Sasso
Biomed. Opt. Express 10(4) 1870-1881 (2019)

Raman spectroscopic studies of diamond in Intralipid

Charles A. Thompson, Jeffery S. Reynolds, Kevin J. Webb, Fred P. LaPlant, and Dor Ben-Amotz
Opt. Lett. 20(10) 1195-1197 (1995)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved