Abstract

One-second quantitative measurements are achieved by employing time-correlated single-photon counting detection and a software time-filter for signal-to-noise ratio enhancement. Fast collection times are accomplished by configuring a commercial time-to-amplitude converter in the reverse-interactive mode. In such a configuration, instrumental sensitivity is enhanced sixfold over that for the conventional-noninteractive configuration, and photon-processing rates can be as high as 125 kHz. The linear range for the one-second measurement is greater than three orders in magnitude, the sensitivity is 4.6 × 10¹⁴ counts M⁻¹ s⁻¹, and the extrapolated lower limit of detection for solutions of β-carboline in 0.5 M sulfuric acid is about 2 × 10⁻¹³ M.

Achieving a high photon count rate in digital time-correlated single photon counting using a hybrid photodetector

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Opt. Express 29(7) 9797-9804 (2021)

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Underwater depth imaging using time-correlated single-photon counting

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Multifocal multiphoton excitation and time correlated single photon counting detection for 3-D fluorescence lifetime imaging

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Opt. Express 15(20) 12548-12561 (2007)

Increasing the collection efficiency of time-correlated single-photon counting with single-photon avalanche diodes using immersion lenses

Charles Pichette, Andrea Giudice, Simon Thibault, and Yves Bérubé-Lauzière
Appl. Opt. 55(33) 9555-9562 (2016)