Abstract

Near-infrared reflectance (NIR) spectroscopy, which has become a widely used technique in food analysis, also holds considerable promise as a nondestructive and noninvasive probe for clinical diagnosis and examinations. Since the light in the near-infrared region is able to penetrate human tissues sufficiently, the use of the NIR technique may enable one to extract useful information directly from a human body without any pain and injury. However, in spite of the potentiality of NIR spectroscopy in medicine, its applications to clinical problems are still very limited; so far, most near-infrared spectroscopic studies in the medical field are concerned with the estimation of body fat and with the quantification of cerebral oxygenation and hemodynamics. Therefore, we have started working toward novel applications of the NIR method to medical problems. In this note we demonstrate the usefulness of NIR spectroscopy with fiber optics in the noninvasive monitoring of deoxyhemoglobin in the vein; it is possible to obtain <i>in vivo</i> NIR spectra of venous blood from various parts of the human body surface, with a high signal-to-noise ratio.

Multiwavelength optoacoustic system for noninvasive monitoring of cerebral venous oxygenation: a pilot clinical test in the internal jugular vein

Yuriy Y. Petrov, Irina Y. Petrova, Igor A. Patrikeev, Rinat O. Esenaliev, and Donald S. Prough
Opt. Lett. 31(12) 1827-1829 (2006)

Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system

I. Y. Petrova, Y. Y. Petrov, R. O. Esenaliev, D. J. Deyo, I. Cicenaite, and D. S. Prough
Opt. Express 17(9) 7285-7294 (2009)

Noninvasive monitoring of estrogen effects against ischemic stroke in rats by near-infrared spectroscopy

Mengna Xia, Shaohua Yang, James W. Simpkins, and Hanli Liu
Appl. Opt. 46(34) 8315-8321 (2007)

In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system

H. P. Brecht, D. S. Prough, Y. Y. Petrov, I. Patrikeev, I. Y. Petrova, D. J. Deyo, I. Cicenaite, and R. O. Esenaliev
Opt. Express 15(24) 16261-16269 (2007)

Monitoring of fruit freshness using phase information in polarization reflectance spectroscopy

M. Sarkar, N. Gupta, and M. Assaad
Appl. Opt. 58(23) 6396-6405 (2019)