OSA's Digital Library

Applied Spectroscopy

Applied Spectroscopy

| PUBLISHED BY SAS — AVAILABLE FROM SAS AND OSA

  • Vol. 47, Iss. 6 — Jun. 1, 1993
  • pp: 787–791

Raman Spectroscopic Characterization of Human Breast Tissues: Implications for Breast Cancer Diagnosis

Douglas C. B. Redd, Zhe Chuan Feng, Kwok To Yue, and Ted S. Gansler

Applied Spectroscopy, Vol. 47, Issue 6, pp. 787-791 (1993)


View Full Text Article

Acrobat PDF (570 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Development and application of laser-based diagnostic and therapeutic procedures have been hindered by the current technical inadequacies in tissue diagnosis and characterization. It is now possible to apply the techniques of Raman spectroscopy to achieve rapid, noninvasive, and nondestructive differentiation of diseased from normal tissues. Normal and diseased breast tissues were examined by Raman spectroscopy. The Raman spectra obtained contain features that are attributable to various amounts of carotenoids and lipids. A small contribution from a heme-type signal was detected in some samples of clinically abnormal yet histopathologically benign breast tissue, while a much stronger heme-type signal was detected in most of the breast cancers. Raman spectra of diseased breast tissue (benign and malignant) also show markedly diminished to absent contributions from lipids and reduced contributions from carotenoids. This laser-based spectroscopic modality is readily adaptable to reflected light microscopy and optical fiber techniques, making it potentially useful as an aid in real-time diagnosis, and may thus find application in the fields of histopathology and interventional radiology.

Citation
Douglas C. B. Redd, Zhe Chuan Feng, Kwok To Yue, and Ted S. Gansler, "Raman Spectroscopic Characterization of Human Breast Tissues: Implications for Breast Cancer Diagnosis," Appl. Spectrosc. 47, 787-791 (1993)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-47-6-787

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you are accessing the full text through a member bundle, please use the Enhanced HTML link to gain access to the citation lists and other restricted features. Note that accessing both the PDF and HTML versions of an article will count as only one download against your account.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you are accessing the full text through a member bundle, please use the Enhanced HTML link to gain access to the citation lists and other restricted features. Note that accessing both the PDF and HTML versions of an article will count as only one download against your account.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited