Abstract

The IR spectra of dry films of synovial fluid from normal and arthritic joints are presented. The spectra suggest the existence of CO₂ clathrates in these fluids which are of remarkable stability in comparison to wellknown CO₂ clathrate hydrates. To our knowledge, this is the first demonstration of the formation of CO₂ clathrates in biological media. The proportion of CO₂ clathrates found in synovial fluid appears to vary with the state of health of joints and thus may be of use in the clinical diagnosis of arthritis.

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