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  • Applied Spectroscopy
  • Vol. 48,
  • Issue 5,
  • pp. 545-548
  • (1994)

Micron Surface-Enhanced Raman Spectroscopy of Intact Biological Organisms and Model Systems

Elizabeth A. Todd and Michael D. Morris

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Abstract

Surface-enhanced Raman spectra have been obtained within intact zebrafish embryos and inside the 500-fL pores of a Nucleopore filter membrane with the use of coated microelectrodes with 1-3 μm active silver tip diameters. The spectra obtained demonstrate the microelectrode's ability to penetrate biological membranes as well as restricted volumes.

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