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Applied Spectroscopy

Applied Spectroscopy

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  • Vol. 50, Iss. 2 — Feb. 1, 1996
  • pp: 285–291

Depth-Resolved Near-Infrared Spectroscopy

Nadhamuni G. Nerella and James K. Drennen

Applied Spectroscopy, Vol. 50, Issue 2, pp. 285-291 (1996)


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Abstract

While there is substantial evidence proving the success of transdermal drug delivery, there have been few accomplishments in the area of depth-resolved prediction of drug concentration during diffusion through a matrix. Such a method for noninvasive quantification of a diffusing species could assist in the development of new drugs, dosage forms, and penetration enhancers. Near-infrared depth-resolved measurements were accomplished by strategically controlling the amount of reflected light reaching the detectors using a combination of diaphragms with different-diameter apertures. Near-IR spectra were collected from a set of cellulose and Silastic® membranes to prove the possibility of depth-resolved near-IR measurements. Principal component regression was used to estimate the depth resolution of this method, yielding an average resolution of 31 μm. Further, to demonstrate depth-resolved near-IR spectroscopy in a practical in vitro system, we determined concentrations of salicylic acid (SA) in a hydrogel matrix during diffusion experiments carried out for up to three hours. An artificial-neural-network-based calibration model was developed which predicted SA concentrations accurately (R2 = 0.993, SEP = 123 μg/mL).

Citation
Nadhamuni G. Nerella and James K. Drennen, "Depth-Resolved Near-Infrared Spectroscopy," Appl. Spectrosc. 50, 285-291 (1996)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-50-2-285

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