OSA's Digital Library

Applied Spectroscopy

Applied Spectroscopy

| PUBLISHED BY SAS — AVAILABLE FROM SAS AND OSA

  • Vol. 53, Iss. 8 — Aug. 1, 1999
  • pp: 954–959

Surface-Enhanced Raman Scattering Detection of Amphetamine and Methamphetamine by Modification with 2-Mercaptonicotinic Acid

Roberta A. Sulk, Robert C. Corcoran, and Keith T. Carron

Applied Spectroscopy, Vol. 53, Issue 8, pp. 954-959 (1999)


View Full Text Article

Acrobat PDF (228 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

We have demonstrated the use of surface-enhanced Raman scattering (SERS) spectroscopy for the detection of the phenylalkylamines amphetamine and methamphetamine. This work can be viewed as the first phase of development toward a one-step drug detection method with a selective reactive coating on a SERS substrate. This work involves a fairly complicated coupling reaction prior to surface derivatization. Future efforts will be directed at creating a reactive coating directly on the surface. The amines were derivatized by a coupling reaction with 2-mercaptonicotinic acid (2-MNA) with the use of dicyclohexylcarbodiimide (DCC) as the coupling reagent to form the amide compounds AMNA [N-(1-methyl-2-phenylethyl)2-mercaptopyridine-3-carboxamide] and MMNA [N-methyl-N-(1-methyl-2-phenylethyl)-2-mercaptopyridine-3-carboxamide]. The amides were qualitatively identified from SERS spectra. Quantification of the amides was accomplished by adding the internal standard pentachlorothiophenol (PCTP) and measuring the intensity of Raman bands of the analyte relative to a Raman band of the internal standard. Calibration curves were plotted of the relative peak intensity ratios as a function of analyte concentration. Detection limits of 19 ppm and 17 ppm were found for amphetamine/2-MNA (AMNA) amide and methamphetamine/2-MNA (MMNA) amide, respectively.

Citation
Roberta A. Sulk, Robert C. Corcoran, and Keith T. Carron, "Surface-Enhanced Raman Scattering Detection of Amphetamine and Methamphetamine by Modification with 2-Mercaptonicotinic Acid," Appl. Spectrosc. 53, 954-959 (1999)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-53-8-954


Sort:  Journal  |  Reset

References

References are not available for this paper.

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited