A new method to rapidly produce and screen biodegradable polymer- and xerogel-based formulations is described. The approach is based on a high-speed pin printer and imaging with an epi-fluorescence microscope/charge-coupled device detector. By using this approach we can produce and screen over 600 formulations/h and rapidly identify lead formulations and/or compositions that are the most useful for the development of biodegradable devices or (bio)sensors.
Eun Jeong Cho, Zunyu Tao, Ying Tang, Elizabeth C. Tehan, Frank V. Bright, Wesley L. Hicks, Joseph A. Gardella, and Robert Hard, "Tools to Rapidly Produce and Screen Biodegradable Polymer and Sol-Gel-Derived Xerogel Formulations," Appl. Spectrosc. 56, 1385-1389 (2002)