Abstract

A simple procedure for the recovery of deep subsurface Raman spectra in stratified turbid samples by defocusing a conventional Raman instrument is presented. The method is based on effects present with spatially offset Raman spectroscopy (SORS) and, although not as efficient as the standard SORS approach, it permits a simple way of recovering subsurface Raman spectra from less challenging samples. Demonstration of the effect is performed using a standard SORS device and a commercial Raman instrument on the noninvasive measurement of paracetamol tablets held within a nontransparent white plastic bottle.

DMD-based software-configurable spatially-offset Raman spectroscopy for spectral depth-profiling of optically turbid samples

Zhiyu Liao, Faris Sinjab, Graham Gibson, Miles Padgett, and Ioan Notingher
Opt. Express 24(12) 12701-12712 (2016)

Hyperspectral spatially offset Raman spectroscopy in a microfluidic channel

Moritz Matthiae and Anders Kristensen
Opt. Express 27(3) 3782-3790 (2019)

Three-dimensional imaging of objects embedded in turbid media with fluorescence and Raman spectroscopy

Jun Wu, Yang Wang, Lev Perelman, Irvine Itzkan, Ramachandra R. Dasari, and Michael S. Feld
Appl. Opt. 34(18) 3425-3430 (1995)

Enhancement of laser radiation coupled into turbid media by using a unidirectional mirror

Pavel Matousek
J. Opt. Soc. Am. B 25(7) 1223-1230 (2008)

Frequency offset Raman spectroscopy (FORS) for depth probing of diffusive media

Sanathana Konugolu Venkata Sekar, Sara Mosca, Andrea Farina, Fabrizio Martelli, Paola Taroni, Gianluca Valentini, Rinaldo Cubeddu, and Antonio Pifferi
Opt. Express 25(5) 4585-4597 (2017)