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Applied Spectroscopy

Applied Spectroscopy


  • Vol. 63, Iss. 5 — May. 1, 2009
  • pp: 512–517

High-Throughput Spectroscopic Imaging Applied to Permeation Through the Skin

Jean-Michel Andanson, K. L. Andrew Chan, and Sergei G. Kazarian

Applied Spectroscopy, Vol. 63, Issue 5, pp. 512-517 (2009)

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Infrared (IR) spectroscopy has been successfully applied to study the permeation of substances through human skin in a high-throughput manner. The sample of skin was placed on the measuring surface of an attenuated total reflection (ATR) crystal and was divided into several areas. These areas were separated using a specially designed grid created on the surface of the skin and each area was subjected to a different combination of permeant and enhancer. ATR Fourier transform infrared (FT-IR) imaging was applied to measure the permeation of 12 liquid samples through a piece of skin smaller than 5 cm2. This work demonstrated that, using the ATR-FT-IR imaging method, it is possible to measure and directly compare the transdermal processes of several permeants under identical conditions.

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Jean-Michel Andanson, K. L. Andrew Chan, and Sergei G. Kazarian, "High-Throughput Spectroscopic Imaging Applied to Permeation Through the Skin," Appl. Spectrosc. 63, 512-517 (2009)

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